Protein Domain : IPR014756

Type:  Domain Name:  Immunoglobulin E-set
Description:  The immunoglobulin (Ig) like fold, which consists of a beta-sandwich of seven or more strands in two sheets with a greek-key topology, is one of the most common protein modules found in animals. Many different unrelated proteins share an Ig-like fold, which is often involved in interactions, commonly with other Ig-like domains via their beta-sheets []. Of these, the "early" set (E set) domains are possibly related to the immunoglobulin () and/or fibronectin type III () Ig-like protein superfamilies. Ig-like E set domains include: C-terminal domain of certain transcription factors, such as the pro-inflammatory transcription factor NF-kappaB, and the T-cell transcription factors NFAT1 and NFAT5 [].Ig-like domains of sugar-utilising enzymes, such as galactose oxidase (C-terminal domain), sialidase (linker domain), and maltogenic amylase (N-terminal domain).C-terminal domain of arthropod haemocyanin, where many loops are inserted into the fold. These proteins act as dioxygen-transporting proteins.C-terminal domain of class II viral fusion proteins. These envelope glycoproteins are responsible for membrane fusion with target cells during viral invasion.Cytomegaloviral US (unique short) proteins. These type I membrane proteins help suppress the host immune response by modulating surface expression of MHC class I molecules [].Molybdenium-containing oxidoreductase-like dimerisation domain found in enzymes such as sulphite reductase.ML domains found in cholesterol-binding epididymal secretory protein E1, and in a major house-dust mite allergen; ML domains are implicated in lipid recognition, particularly the recognition of pathogen-related products.Rho-GDI-like signalling proteins, which regulate the activity of small G proteins [].Cytoplasmic domain of inward rectifier potassium channels such as Girk1 and Kirbac1.1. These channels act as regulators of excitability in eukaryotic cells.N-terminal domain of transglutaminases, including coagulation factor XIII; many loops are inserted into the fold in these proteins. These proteins act to catalyse the cross-linking of various protein substrates [].Filamin repeat rod domain found in proteins such as the F-actin cross-linking gelation factor ABP-120. These proteins interact with a variety of cellular proteins, acting as signalling scaffolds [].Arrestin family of proteins, which contain a tandem repeat of two elaborated Ig-like domains contacting each other head-to-head. These proteins are key to the redirection of GPCR signals to alternative pathways [].C-terminal domain of arginine-specific cysteine proteases, such as Gingipain-R, which act as major virulence factors of Porphyromonas gingivalis(Bacteroides gingivalis).Copper-resistance proteins, such as CopC, which act as copper-trafficking proteins [].Cellulosomal scaffoldin proteins, such as CipC module x2.1. These proteins act as scaffolding proteins of cellulosomes, which contain cellulose-degrading enzymes [].Quinohaemoprotein amine dehydrogenases (A chain), which contain a tandem repeat of two Ig-like domains. These proteins function in electron transfer reactions.Internalin Ig-like domains, which are truncated and fused to a leucine-rich repeat domain. These proteins are required for host cell invasion of Listeria species. Short Name:  Ig_E-set
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16 Child Features

DB identifier Type Name
IPR013518 Domain Potassium channel, inwardly rectifying, Kir, cytoplasmic
IPR003172 Domain MD-2-related lipid-recognition domain
IPR015202 Domain Domain of unknown function DUF1929
IPR002909 Domain IPT domain
IPR005066 Domain Moybdenum cofactor oxidoreductase, dimerisation
IPR024792 Domain Rho GDP-dissociation inhibitor domain
IPR005203 Domain Hemocyanin, C-terminal
IPR014755 Domain Copper resistance protein CopC/internalin, immunoglobulin-like
IPR000336 Domain Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain
IPR023295 Domain Hyaluronate lyase, beta-sheet domain
IPR014749 Domain Herpesvirus US2, cytomegalovirus-type
IPR005102 Domain Carbohydrate binding X2 domain
IPR013540 Domain Chitinase A N-terminal
IPR014880 Domain Sulphur oxidation protein SoxZ
IPR015219 Domain Glucodextranase B
IPR005536 Domain Peptidase C25, Ig-like domain

11 Contains

DB identifier Type Name
IPR004193 Domain Glycoside hydrolase, family 13, N-terminal
IPR017868 Repeat Filamin/ABP280 repeat-like
IPR001298 Repeat Filamin/ABP280 repeat
IPR014752 Domain Arrestin, C-terminal
IPR014753 Domain Arrestin, N-terminal
IPR004197 Domain Glycoside hydrolase, family 9, N-terminal, Ig-like
IPR004185 Domain Glycoside hydrolase, family 13, N-terminal Ig-like domain
IPR001102 Domain Transglutaminase, N-terminal
IPR015183 Domain Quinohemoprotein amine dehydrogenase, alpha subunit domain III
IPR015184 Domain Quinohemoprotein amine dehydrogenase, alpha subunit domain IV
IPR017864 Conserved_site Arrestin, conserved site

1 Cross References

Identifier
SSF81296

12 Found Ins

DB identifier Type Name
IPR006407 Family 1,4-alpha-glucan-branching enzyme, GlgB
IPR011839 Domain Alpha-1,6-glucosidases, pullulanase-type
IPR008015 Family GMP phosphodiesterase, delta subunit
IPR011837 Family Glycogen debranching enzyme, GlgX type
IPR003523 Family Transcription factor COE
IPR012768 Family Malto-oligosyltrehalose trehalohydrolase
IPR014438 Family Glucan biosynthesis, periplasmic, MdoG/D
IPR015171 Domain Cyclomaltodextrinase, N-terminal
IPR009237 Family Herpesvirus US2/US3
IPR017287 Family Retinal rod rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase, delta subunit
IPR000698 Family Arrestin
IPR017803 Domain Conserved hypothetical protein CHP03437, C-terminal, Solibacter usitatus

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
170984 D8RFC1 PAC:15409944 Selaginella moellendorffii 270  
410613 D8RFA6 PAC:15407024 Selaginella moellendorffii 1812  
412212 D8RKG0 PAC:15409931 Selaginella moellendorffii 1140  
8796 D8RKP0 PAC:15407482 Selaginella moellendorffii 79  
441651 D8RLP0 PAC:15409431 Selaginella moellendorffii 550  
441667 D8RLU7 PAC:15409450 Selaginella moellendorffii 982  
432046 D8TET5 PAC:15422781 Selaginella moellendorffii 1113  
231924 D8RMP2 PAC:15420554 Selaginella moellendorffii 904  
165481 D8QUU7 PAC:15413579 Selaginella moellendorffii 782  
26394 D8QW22 PAC:15401354 Selaginella moellendorffii 190  
77935 D8QUK1 PAC:15422348 Selaginella moellendorffii 543  
2346 D8RQI6 PAC:15409213 Selaginella moellendorffii 404  
149167 D8RRC4 PAC:15408425 Selaginella moellendorffii 392  
413959 D8RR64 PAC:15418337 Selaginella moellendorffii 537  
34445 D8RS38 PAC:15403319 Selaginella moellendorffii 255  
3956 D8RT47 PAC:15416744 Selaginella moellendorffii 262  
414611 D8RTC6 PAC:15418860 Selaginella moellendorffii 828  
416480 D8RZE9 PAC:15423216 Selaginella moellendorffii 1365  
138678 D8TFX3 PAC:15402223 Selaginella moellendorffii 347  
106391 D8S1Q0 PAC:15417178 Selaginella moellendorffii 625  
106218 D8S1P2 PAC:15416256 Selaginella moellendorffii 671  
109782 D8S6A3 PAC:15406611 Selaginella moellendorffii 299  
420891 D8SDG1 PAC:15416099 Selaginella moellendorffii 214  
178863 D8SDF9 PAC:15410245 Selaginella moellendorffii 1914  
266879 D8R0S4 PAC:15411501 Selaginella moellendorffii 346  
154776 D8SEU0 PAC:15405633 Selaginella moellendorffii 899  
121538 D8SNZ2 PAC:15418369 Selaginella moellendorffii 239  
144158 D8R544 PAC:15416200 Selaginella moellendorffii 2164  
407438 D8R5L7 PAC:15418976 Selaginella moellendorffii 1810  
123397 D8SRZ6 PAC:15422742 Selaginella moellendorffii 435  

9 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7932691
            12651950
            15380510
            14671122
            15513926
            15290350
            15516996
            15102497
            14756796