Protein Domain : IPR001269

Type:  Family Name:  tRNA-dihydrouridine synthase
Description:  Members of this family catalyse the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also in some archae. Most dihydrouridines are found in the D loop of t-RNAs. The role of dihydrouridine in tRNA is currently unknown, but may increase conformational flexibility of the tRNA. It is likely that different family members have different substrate specificities, which may overlap. Dus 1 () from Saccharomyces cerevisiae(Baker's yeast) acts on pre-tRNA-Phe, while Dus 2 () acts on pre-tRNA-Tyr and pre-tRNA-Leu. Dus 1 is active as a single subunit, requiring NADPH or NADH, and is stimulated by the presence of FAD []. Some family members may be targeted to the mitochondria and even have a role in mitochondria []. Short Name:  tRNA_hU_synthase
Paste the following link

3 Child Features

DB identifier Type Name
IPR004652 Family tRNA-dihydrouridine synthase, TIM-barrel, NifR3
IPR004653 Family tRNA dihydrouridine synthase A
IPR005270 Family tRNA-dihydrouridine synthase, TIM-barrel, NifR3-related

1 Contains

DB identifier Type Name
IPR018517 Conserved_site tRNA-dihydrouridine synthase, conserved site

3 Cross Referencess

Identifier
PTHR11082
PF01207
PIRSF006621

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0017150 IPR001269
GO:0050660 IPR001269
GO:0008033 IPR001269
GO:0055114 IPR001269

4 Ontology Annotations

GO Term Gene Name
GO:0017150 IPR001269
GO:0050660 IPR001269
GO:0008033 IPR001269
GO:0055114 IPR001269

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
174143 D8RTK6 PAC:15415497 Selaginella moellendorffii 319  
104800 D8RYN8 PAC:15414997 Selaginella moellendorffii 358  
443602 D8S2T4 PAC:15415211 Selaginella moellendorffii 378  
409324 D8RB31 PAC:15401630 Selaginella moellendorffii 325  
89139 D8RB36 PAC:15406950 Selaginella moellendorffii 540  
evm.model.supercontig_125.12 PAC:16407240 Carica papaya 376  
evm.model.supercontig_129.26 PAC:16407527 Carica papaya 321  
evm.model.supercontig_150.6 PAC:16409516 Carica papaya 451  
evm.model.supercontig_150.5 PAC:16409505 Carica papaya 265  
evm.model.supercontig_55.107 PAC:16422492 Carica papaya 197  
evm.model.supercontig_55.108 PAC:16422493 Carica papaya 190  
29864.m001493 B9RVP7 PAC:16811803 Ricinus communis 375  
30131.m007147 B9RG59 PAC:16818969 Ricinus communis 686  
34921.m000032 B9TGM1 PAC:16826411 Ricinus communis 329  
29644.m000185 B9T4U6 PAC:16804555 Ricinus communis 426  
28179.m000472 B9SSD6 PAC:16800226 Ricinus communis 330  
Cucsa.103690.1 PAC:16959078 Cucumis sativus 325  
Cucsa.073200.1 PAC:16955582 Cucumis sativus 405  
Cucsa.073200.2 PAC:16955583 Cucumis sativus 300  
Cucsa.249040.1 PAC:16971537 Cucumis sativus 489  
Cucsa.382170.1 PAC:16982289 Cucumis sativus 698  
Cucsa.382170.2 PAC:16982290 Cucumis sativus 696  
orange1.1g013813m A0A067GH93 PAC:18124964 Citrus sinensis 436  
orange1.1g023070m A0A067GHH6 PAC:18124965 Citrus sinensis 287  
orange1.1g026945m A0A067GK90 PAC:18124966 Citrus sinensis 230  
orange1.1g020428m A0A067GGB4 PAC:18124705 Citrus sinensis 326  
orange1.1g005508m A0A067DL76 PAC:18113540 Citrus sinensis 693  
orange1.1g009196m A0A067DUP0 PAC:18113541 Citrus sinensis 540  
orange1.1g013784m A0A067GUY3 PAC:18101424 Citrus sinensis 436  
orange1.1g013796m A0A067GUY3 PAC:18101425 Citrus sinensis 436  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12003496