1 Parent Features
| DB identifier | Type | Name |
|---|---|---|
| IPR029149 | Domain | Creatinase/Aminopeptidase P/Spt16, N-terminal |
| Type: | Domain | Name: | FACT complex subunit Spt16, N-terminal lobe domain |
| Description: | Spt16 is a component of the FACT (facilitator of chromatin transcription) complex, a general chromatin factor that acts to reorganise nucleosomes [, ]. In budding yeasts, the N-terminal domain (NTD) of Spt16 includes a smaller N-terminal lobe (residues 1-175) and a larger C-terminal lobe (residues 176-447). This entry represents the N-terminal lobe domain. Its structure is similar to the RuvC/RNase H family. It may act as a protein-protein interaction domain presumably with partners outside of the FACT complex []. The C-terminal lobe of NTD is structurally similar to aminopeptidases, and the most highly conserved surface residues line a cleft equivalent to the aminopeptidase substrate-binding site in peptidase family M24 (). | Short Name: | FACT-Spt16_Nlobe |
| DB identifier | Type | Name |
|---|---|---|
| IPR029149 | Domain | Creatinase/Aminopeptidase P/Spt16, N-terminal |
