1 Parent Features
| DB identifier | Type | Name |
|---|---|---|
| IPR027291 | Domain | Glycoside hydrolase 38/57, N-terminal domain |
| Type: | Domain | Name: | Glycoside hydrolase family 38, N-terminal domain |
| Description: | O-Glycosyl hydrolases () are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [, ]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site.Glycoside hydrolase family 38 comprises enzymes with only one known activity; alpha-mannosidase () ().Lysosomal alpha-mannosidase is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. The enzyme catalyses the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides, and can cleave all known types of alpha-mannosidic linkages. Defects in the gene cause lysosomal alpha-mannosidosis (AM), a lysosomal storage disease characterised by the accumulation of unbranched oligo-saccharide chains.This entry represents the N-terminal domain of the glycoside hydrolase 38 family protein. | Short Name: | Glyco_hydro_38_N |
| DB identifier | Type | Name |
|---|---|---|
| IPR027291 | Domain | Glycoside hydrolase 38/57, N-terminal domain |
