1 Parent Features
| DB identifier | Type | Name |
|---|---|---|
| IPR011330 | Domain | Glycoside hydrolase/deacetylase, beta/alpha-barrel |
| Type: | Domain | Name: | Glycoside hydrolase 38/57, N-terminal domain |
| Description: | This entry represents a structural domain found in glycoside hydrolase families 38 (, e.g. alpha-mannosidase) [] and 57 (, e.g. 4-alpha-glucanotransferase, N-terminal) [].O-Glycosyl hydrolases () are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [, ]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site.Glycoside hydrolase family 38 comprises enzymes with only one known activity; alpha-mannosidase () ().Lysosomal alpha-mannosidase is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. The enzyme catalyses the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides, and can cleave all known types of alpha-mannosidic linkages. Defects in the gene cause lysosomal alpha-mannosidosis (AM), a lysosomal storage disease characterised by the accumulation of unbranched oligo-saccharide chains.Glycoside hydrolase family 57 comprises enzymes with two known activities; alpha-amylase () and 4-alpha-glucanotransferase (). | Short Name: | Glyco_hydro_38/57_N |
| DB identifier | Type | Name |
|---|---|---|
| IPR011330 | Domain | Glycoside hydrolase/deacetylase, beta/alpha-barrel |
