1 Found In
| DB identifier | Type | Name |
|---|---|---|
| IPR016685 | Family | RNA-induced silencing complex, nuclease component Tudor-SN |
| Type: | Domain | Name: | Tudor domain |
| Description: | The drosophila tudor protein is encoded by a 'posterior group' gene, which when mutated disrupt normal abdominal segmentation and polecell formation. Another drosophila gene, homeless, is required for RNA localization during oogenesis. The tudor protein containsmultiple repeats of a domain which is also found in homeless [].The tudor domain is found in many proteins that colocalise with ribonucleoprotein or single-strand DNA-associated complexes in thenucleus, in the mitochondrial membrane, or at kinetochores. It is not known whether the domain binds directly to RNA and ssDNA, orcontrols interactions with the nucleoprotein complexes. At least one tudor-containing protein, homeless, also contains a zinc fingertypical of RNA-binding proteins [].The resolution of the solution structure of the Tudor domain of human SMN revealed that the Tudor domain forms a strongly bent antiparallel beta-sheet with five strands forming a barrel-like fold. The structure exhibits a conserved negatively charged surface that interacts with the C-terminal Arg and Gly-rich tails of the spliceosomal Sm D1 and D3 proteins []. | Short Name: | Tudor |
| DB identifier | Type | Name |
|---|---|---|
| IPR016685 | Family | RNA-induced silencing complex, nuclease component Tudor-SN |
