Protein Domain : IPR004790

Type:  Family Name:  Isocitrate dehydrogenase NADP-dependent
Description:  Isocitrate dehydrogenase (IDH) [, ] is an important enzyme of carbohydrate metabolism which catalyzes the oxidative decarboxylation of isocitrate into alpha-ketoglutarate. IDH is either dependent on NAD+() or on NADP+(). In eukaryotes there are at least three isozymes of IDH: two are located in the mitochondrial matrix (one NAD+-dependent, the other NADP+-dependent), while the third one (also NADP+-dependent) is cytoplasmic. In Escherichia colithe activity of a NADP+-dependent form of the enzyme is controlled by the phosphorylation of a serine residue; the phosphorylated form of IDH is completely inactivated.The eukaryotic, NADP-dependent isocitrate dehydrogenases, are defined by this family that includes cytosolic, mitochondrial, and chloroplast enzymes, as well as bacterial proteins. This family differs considerably from other isocitrate dehydrogenases that are included in a different group together with 3-isopropylmalate dehydrogenases and tartrate dehydrogenases. Short Name:  Isocitrate_DH_NADP
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0 Child Features

1 Contains

DB identifier Type Name
IPR019818 Conserved_site Isocitrate/isopropylmalate dehydrogenase, conserved site

3 Cross Referencess

Identifier
PTHR11822
PIRSF000108
TIGR00127

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0004450 IPR004790
GO:0006102 IPR004790
GO:0055114 IPR004790

3 Ontology Annotations

GO Term Gene Name
GO:0004450 IPR004790
GO:0006102 IPR004790
GO:0055114 IPR004790

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
267315 D8RFG1 PAC:15410468 Selaginella moellendorffii 418  
84397 D8R492 PAC:15416393 Selaginella moellendorffii 416  
evm.model.supercontig_108.34 PAC:16405449 Carica papaya 486  
evm.model.supercontig_118.2 PAC:16406476 Carica papaya 221  
evm.model.supercontig_118.1 PAC:16406465 Carica papaya 324  
evm.model.supercontig_178.11 PAC:16411140 Carica papaya 369  
evm.model.supercontig_178.15 PAC:16411144 Carica papaya 412  
29880.m000365 B9SMI9 PAC:16812021 Ricinus communis 416  
27914.m000430 B9SR98 PAC:16799499 Ricinus communis 413  
Cucsa.011380.2 PAC:16951414 Cucumis sativus 472  
Cucsa.278250.1 PAC:16974140 Cucumis sativus 410  
orange1.1g040623m A0A067F278 PAC:18133518 Citrus sinensis 443  
orange1.1g015139m A0A067DU62 PAC:18129229 Citrus sinensis 412  
orange1.1g015124m A0A067DUK5 PAC:18129228 Citrus sinensis 413  
orange1.1g016110m A0A067DU66 PAC:18129230 Citrus sinensis 395  
orange1.1g018941m A0A067E6L2 PAC:18129231 Citrus sinensis 348  
orange1.1g019837m A0A067DY74 PAC:18129233 Citrus sinensis 335  
orange1.1g018978m A0A067E6L2 PAC:18129232 Citrus sinensis 348  
orange1.1g021428m A0A067DUL7 PAC:18129234 Citrus sinensis 312  
orange1.1g015043m A0A067DUL2 PAC:18129225 Citrus sinensis 414  
orange1.1g015012m A0A067E5M7 PAC:18129224 Citrus sinensis 414  
orange1.1g015002m A0A067E5M7 PAC:18129226 Citrus sinensis 414  
orange1.1g015008m A0A067E5M7 PAC:18129227 Citrus sinensis 414  
orange1.1g011214m PAC:18121173 Citrus sinensis 491  
orange1.1g010485m PAC:18121172 Citrus sinensis 509  
orange1.1g011846m PAC:18121174 Citrus sinensis 476  
orange1.1g016961m PAC:18121175 Citrus sinensis 380  
AT5G14590.1 Q8LPJ5 PAC:19668890 Arabidopsis thaliana 485  
AT1G65930.1 Q9SRZ6 PAC:19656778 Arabidopsis thaliana 410  
AT1G54340.1 Q9SLK0 PAC:19657336 Arabidopsis thaliana 416  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1939242
            2682654