Type: | Domain | Name: | Smaug, pseudo-HEAT analogous topology |
Description: | The PHAT (pseudo-HEAT analogous topology) domain assumes a structure consisting of a layer of three parallel helices packed against a layer of two antiparallel helices, into a cylindrical shaped five-helix bundle. It is found in the RNA-binding protein Smaug, where it is essential for high-affinity RNA binding []. Smaug is a translation regulator that binds to the 3'-UTR of specific mRNAs such as nanos (nos) and prevents their translation []. | Short Name: | PHAT_dom |