Protein Domain : IPR016024

Type:  Domain Name:  Armadillo-type fold
Description:  This entry represents a structural domain with an armadillo (ARM)-like fold, consisting of a multi-helical fold comprised of two curved layers of alpha helices arranged in a regular right-handed superhelix, where the repeats that make up this structure are arranged about a common axis []. These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. Domains and repeats with an ARM-like fold have been found in a number of proteins, including:ARM repeat domain, found in beta-catenins, importins, karyopherin and exportins.HEAT repeat domain, found in protein phosphatase 2a and initiation factor eIF4G.PHAT domain, found in the RNA-binding protein Smaug.Leucine-rich repeat variant, which contain an FeS cluster.Pumilo repeat domain, found in Pumilo protein.Regulatory subunit H of V-type ATPases.PBS lyase HEAT-like repeat.Mo25 protein.MIF4G domain-like, found in eukaryotic initiation factor eIF4G, translation initiation factor eIF-2b epsilon and nuclear cap-binding protein CBP80.The N-terminal domain of eukaryotic translation initiation factor 3 subunit 12.The C-terminal domain of leukotriene A4 hydrolase.The helical domain of phosphoinositide 3-kinase.The N-terminal fragment of adaptin alpha-C and beta subunits.The proximal leg segment and the linker domain of the clathrin heavy chain.The sequence similarity among these different repeats or domains is low, however they exhibit considerable structural similarity. Furthermore, the number of repeats present in the superhelical structure can vary between orthologues, indicating that rapid loss/gain of repeats has occurred frequently in evolution. A common phylogenetic origin has been proposed for the armadillo and HEAT repeats []. Short Name:  ARM-type_fold
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8 Child Features

DB identifier Type Name
IPR015211 Domain Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal
IPR011989 Domain Armadillo-like helical
IPR003307 Domain W2 domain
IPR016021 Domain MIF4G-like domain
IPR001263 Domain Phosphoinositide 3-kinase, accessory (PIK) domain
IPR015327 Domain Smaug, pseudo-HEAT analogous topology
IPR016020 Domain Translation initiation factor 3, subunit 12, N-terminal, eukaryotic
IPR014768 Domain Rho GTPase-binding/formin homology 3 (GBD/FH3) domain

38 Contains

DB identifier Type Name
IPR012993 Domain UME
IPR012977 Domain Uncharacterised domain NUC130/133, N-terminal
IPR010314 Domain E3 ubiquitin ligase, domain of unknown function DUF913
IPR015172 Domain MIF4G-like, type 1
IPR015174 Domain MIF4G-like, type 2
IPR013721 Domain STAG
IPR020839 Domain Stromalin conservative domain
IPR007205 Domain Protein HGH1 N-terminal
IPR004155 Repeat PBS lyase HEAT-like repeat
IPR021133 Repeat HEAT, type 2
IPR000225 Repeat Armadillo
IPR003890 Domain MIF4G-like, type 3
IPR006953 Domain Vesicle tethering protein Uso1/P115-like , head domain
IPR006955 Domain Uso1/p115-like vesicle tethering protein, C-terminal
IPR013713 Domain Exportin/Importin, Cse1-like
IPR015403 Domain Domain of unknown function DUF1981, Sec7 associated
IPR012583 Domain Pre-rRNA-processing protein RIX1, N-terminal
IPR016021 Domain MIF4G-like domain
IPR000547 Repeat Clathrin, heavy chain/VPS, 7-fold repeat
IPR013180 Domain Beta-catenin-like protein 1, N-terminal
IPR022707 Domain Domain of unknown function DUF3535
IPR000357 Repeat HEAT repeat
IPR011987 Domain ATPase, V1 complex, subunit H, C-terminal
IPR012978 Domain Uncharacterised domain NUC173
IPR002015 Repeat Proteasome/cyclosome repeat
IPR015348 Domain Clathrin, heavy chain, linker, core motif
IPR007701 Domain Interferon-related developmental regulator, N-terminal
IPR006887 Domain Domain of unknown function DUF625
IPR011430 Domain Down-regulated-in-metastasis protein
IPR022716 Domain Domain of unknown function DUF3554

1 Cross References

Identifier
SSF48371

16 Found Ins

DB identifier Type Name
IPR016528 Family Vacuolar protein sorting-associated protein 11
IPR008383 Family Apoptosis inhibitory 5
IPR016460 Family Coatomer beta subunit (COPB1)
IPR016902 Family Vacuolar protein sorting-associated protein 41
IPR004083 Family Regulatory associated protein of TOR
IPR004908 Family ATPase, V1 complex, subunit H
IPR013878 Family Mo25-like
IPR016341 Family Clathrin, heavy chain
IPR012502 Family Wings apart-like, metazoan/plants
IPR016643 Family 26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit
IPR014825 Family DNA alkylation repair enzyme
IPR012371 Family Condensin-2 complex subunit D3
IPR003913 Family Tuberin
IPR017212 Family Clathrin, heavy chain-related
IPR000091 Family Huntingtin
IPR016441 Family TEL2-interacting protein 1

1 GO Annotation

GO Term Gene Name
GO:0005488 IPR016024

1 Ontology Annotations

GO Term Gene Name
GO:0005488 IPR016024

0 Parent Features

153388 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
146848 D8RG19 PAC:15404934 Selaginella moellendorffii 484  
171199 D8RG53 PAC:15406720 Selaginella moellendorffii 1283  
410663 D8RFG5 PAC:15407140 Selaginella moellendorffii 740  
410901 D8RG84 PAC:15409416 Selaginella moellendorffii 1272  
440923 D8RFF3 PAC:15408682 Selaginella moellendorffii 1180  
440913 D8RFB7 PAC:15408656 Selaginella moellendorffii 1701  
441002 D8RFY3 PAC:15404615 Selaginella moellendorffii 623  
73073 D8RFV3 PAC:15403819 Selaginella moellendorffii 101  
269945 D8TAD9 PAC:15420906 Selaginella moellendorffii 957  
171350 D8RGL1 PAC:15408091 Selaginella moellendorffii 548  
61948 D8RHP8 PAC:15420046 Selaginella moellendorffii 352  
162778 D8TBU8 PAC:15406947 Selaginella moellendorffii 1469  
172230 D8RKK7 PAC:15410363 Selaginella moellendorffii 408  
412413 D8RL27 PAC:15411503 Selaginella moellendorffii 922  
172660 D8RMD2 PAC:15413499 Selaginella moellendorffii 723  
97360 D8RMQ9 PAC:15410005 Selaginella moellendorffii 803  
97324 D8RMV0 PAC:15409901 Selaginella moellendorffii 1072  
141341 D8QVR5 PAC:15408863 Selaginella moellendorffii 4668  
141399 D8QW38 PAC:15408989 Selaginella moellendorffii 451  
1983 D8QV41 PAC:15411026 Selaginella moellendorffii 337  
165698 D8QW17 PAC:15415126 Selaginella moellendorffii 866  
230150 D8QVZ4 PAC:15411601 Selaginella moellendorffii 445  
404572 D8QVR9 PAC:15411100 Selaginella moellendorffii 1455  
404660 D8QW06 PAC:15411803 Selaginella moellendorffii 1715  
78052 D8QUB8 PAC:15418509 Selaginella moellendorffii 340  
78497 D8QU44 PAC:15421560 Selaginella moellendorffii 353  
78585 D8QUV8 PAC:15422327 Selaginella moellendorffii 340  
78846 D8QW39 PAC:15402275 Selaginella moellendorffii 2105  
78845 D8QW92 PAC:15402274 Selaginella moellendorffii 1247  
148739 D8RNY3 PAC:15410117 Selaginella moellendorffii 804  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10361086
            11551174