| Type: | Repeat | Name: | HEAT repeat |
| Description: | The HEAT repeat is a tandemly repeated, 37-47 amino acid long module occurring in a number of cytoplasmic proteins, including the fourname-giving proteins huntingtin, elongation factor 3 (EF3), the 65 Kd alpha regulatory subunit of protein phosphatase 2A (PP2A) and theyeast PI3-kinase TOR1 []. Arrays of HEAT repeats consists of 3 to 36units forming a rod-like helical structure and appear to function as protein-protein interaction surfaces. It has been noted that manyHEAT repeat-containing proteins are involved in intracellular transport processes.In the crystal structure of PP2A PR65/A [], the HEAT repeats consistof pairs of antiparallel alpha helices []. | Short Name: | HEAT |
