Protein Domain : IPR004094

Type:  Domain Name:  Antistasin-like domain
Description:  Antistatin is a small, disulphide cross-linked serine protease inhibitor isolated from the salivary glands of the Mexican leech. It is a potentanticoagulant by virtue of its ability to inhibit factor Xa in the coagulation cascade. Antistatin also exhibits a strong antimetastatic activity. Itcontains internal repeats of a 25-26 amino acid sequence with a highly conserved pattern of 6 cysteine (Cys) and 2 glycine residues []. Manymetazoan proteins share sequence homology with this antistasin-like domain. The unique physical properties of these related Cys-rich proteins (proteaseresistance; heat, chemical resilience) appear to stem from the common six Cys loop that is cross-linked by three disulfide bonds []. Disulfide linkages are between Cys1-Cys4, Cys2-Cys5, and Cys3-Cys6 [, ].The antistasin-like domain consists of very short antiparallel beta-sheets and interacts with proteinases []. Short Name:  Antistasin-like
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0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF02822
PS51252
G3DSA:2.10.22.10

1 Found In

DB identifier Type Name
IPR008086 Family Proteinase inhibitor I15, leech antistasin

1 GO Annotation

GO Term Gene Name
GO:0004867 IPR004094

1 Ontology Annotations

GO Term Gene Name
GO:0004867 IPR004094

1 Parent Features

DB identifier Type Name
IPR011061 Domain Hirudin/antistatin

80 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
AT4G29273.1 P82737 PAC:19646207 Arabidopsis thaliana 77  
Araha.7859s0001.1.p PAC:28844847 Arabidopsis halleri 77  
Cagra.16826s0002.1.p PAC:28915324 Capsella grandiflora 79  
Glyma.18G069600.1.p A0A0R0F7C8 PAC:30557735 Glycine max 87  
Bostr.7867s0779.1.p PAC:30657509 Boechera stricta 77  
Spipo21G0009600 PAC:31505138 Spirodela polyrhiza 800  
evm_27.model.AmTr_v1.0_scaffold00001.568 W1NMH3 PAC:31551451 Amborella trichopoda 246  
Traes_6BL_077C91EAE.5 PAC:31986745 Triticum aestivum 180  
Prupe.6G145400.1.p M5W411 PAC:32085926 Prunus persica 74  
Kalax.0327s0035.4.p PAC:32542203 Kalanchoe laxiflora 506  
Kalax.0327s0035.3.p PAC:32542204 Kalanchoe laxiflora 504  
LOC_Os06g37790.1 PAC:33149849 Oryza sativa 570  
Kaladp0011s1030.4.p PAC:35755976 Kalanchoe fedtschenkoi 516  
Kaladp0011s1030.3.p PAC:35755977 Kalanchoe fedtschenkoi 514  
AT4G29273.1 P82737 PAC:37387052 Arabidopsis thaliana 77  
Pavir.4KG285400.1.p PAC:37607470 Panicum virgatum 192  
Sobic.004G275400.1.p C5Y0R9 PAC:37933593 Sorghum bicolor 387  
Gohir.D11G246000.4.p PAC:38079616 Gossypium hirsutum 156  
Gohir.D11G246000.9.p PAC:38079617 Gossypium hirsutum 156  
Gohir.D11G246000.3.p PAC:38079614 Gossypium hirsutum 171  
Gohir.D11G246000.7.p PAC:38079615 Gossypium hirsutum 158  
Gohir.D11G246000.10.p PAC:38079621 Gossypium hirsutum 138  
Gohir.D11G246000.2.p PAC:38079613 Gossypium hirsutum 171  
Gohir.D11G246000.1.p PAC:38079612 Gossypium hirsutum 173  
HORVU6Hr1G067020.3 PAC:38496827 Hordeum vulgare 331  
HORVU6Hr1G067020.4 PAC:38496826 Hordeum vulgare 331  
HORVU1Hr1G045610.5 PAC:38465880 Hordeum vulgare 286  
HORVU5Hr1G060910.1 PAC:38435865 Hordeum vulgare 286  
Brahy.S08G0022800.1.p PAC:38660502 Brachypodium hybridum 106  
SbRio.04G293100.1.p C5Y0R9 PAC:39008934 Sorghum bicolor Rio 387  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10512718
            1516699
            15013771
            16523290