Protein Domain : IPR004404

Type:  Family Name:  Dihydroxy-acid dehydratase
Description:  Two dehydratases, dihydroxy-acid dehydratase (gene ilvD or ILV3) and 6-phosphogluconate dehydratase (gene edd) have been shown to be evolutionary related []. Dihydroxy-aciddehydratase catalyzes the fourth step in the biosynthesis of isoleucine and valine, the dehydratation of 2,3-dihydroxy-isovaleic acid into alpha-ketoisovaleric acid. 6-Phosphogluconate dehydratase catalyzes thefirst step in the Entner-Doudoroff pathway, the dehydratation of 6-phospho-D-gluconate into 6-phospho-2-dehydro-3-deoxy-D-gluconate. Another protein containing this signature is the Escherichia colihypothetical protein yjhG. The N-terminal part of the proteins contains a cysteine that could be involved in the binding of a2Fe-2S iron-sulphur cluster [].This family represents dihydroxy-acid dehydratase (DAD). It contains a catalytically essential [4Fe-4S] cluster and catalyses the fourth step in valine and isoleucine biosynthesis. Short Name:  DihydroxyA_deHydtase
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0 Child Features

1 Contains

DB identifier Type Name
IPR020558 Conserved_site Dihydroxy-acid/6-phosphogluconate dehydratase, conserved site

2 Cross Referencess

Identifier
TIGR00110
MF_00012

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0004160 IPR004404
GO:0009082 IPR004404

2 Ontology Annotations

GO Term Gene Name
GO:0004160 IPR004404
GO:0009082 IPR004404

1 Parent Features

DB identifier Type Name
IPR000581 Family Dihydroxy-acid/6-phosphogluconate dehydratase

354 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
165632 D8QVL8 PAC:15415005 Selaginella moellendorffii 608  
evm.model.supercontig_59.101 PAC:16423107 Carica papaya 617  
29904.m002982 B9RWL5 PAC:16812627 Ricinus communis 615  
Cucsa.256250.1 A0A0A0L6U0 PAC:16972510 Cucumis sativus 620  
orange1.1g007192m A0A067DKU2 PAC:18119307 Citrus sinensis 613  
AT3G23940.1 Q9LIR4 PAC:19658715 Arabidopsis thaliana 608  
AT3G23940.2 Q9LIR4 PAC:19658716 Arabidopsis thaliana 606  
Thhalv10002451m V4LBR5 PAC:20196677 Eutrema salsugineum 605  
Ciclev10004565m V4S0R8 PAC:20791136 Citrus clementina 613  
Lus10033370 PAC:23172161 Linum usitatissimum 608  
Lus10034822 PAC:23142208 Linum usitatissimum 608  
Potri.001G051700.1 B9GMG3 PAC:27047569 Populus trichocarpa 611  
Potri.003G176600.2 PAC:26999091 Populus trichocarpa 557  
Potri.003G176600.1 B9H085 PAC:26999089 Populus trichocarpa 603  
Potri.003G176600.3 PAC:26999090 Populus trichocarpa 591  
Gorai.005G035200.1 A0A0D2R8M0 PAC:26804235 Gossypium raimondii 606  
35014 I0Z6M5 PAC:27393090 Coccomyxa subellipsoidea C-169 582  
148584 C1MJD7 PAC:27345236 Micromonas pusilla CCMP1545 575  
90156 C1DZG4 PAC:27396307 Micromonas sp RCC299 566  
34354 A4RUR5 PAC:27413431 Ostreococcus lucimarinus 567  
Thecc1EG020385t1 A0A061EST7 PAC:27451746 Theobroma cacao 606  
Migut.N00344.1.p A0A022QV93 PAC:28926215 Mimulus guttatus 611  
Araha.0732s0002.1.p PAC:28844879 Arabidopsis halleri 571  
Araha.11756s0258.1.p PAC:28856259 Arabidopsis halleri 617  
Cagra.0026s0003.1.p PAC:28919759 Capsella grandiflora 609  
Glyma.13G207900.1.p I1M137 PAC:30500221 Glycine max 601  
Brara.A02588.1.p A0A398ASH3 PAC:30638782 Brassica rapa FPsc 609  
Brara.G00612.1.p A0A397YIA2 PAC:30633053 Brassica rapa FPsc 507  
Bostr.19424s0200.1.p PAC:30660806 Boechera stricta 608  
Cre03.g206600.t1.2 A8IX80 PAC:30787719 Chlamydomonas reinhardtii 604  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8299945
            1624451