Protein Domain : IPR000581

Type:  Family Name:  Dihydroxy-acid/6-phosphogluconate dehydratase
Description:  Two dehydratases, dihydroxy-acid dehydratase () (gene ilvD or ILV3) and 6-phosphogluconate dehydratase () (gene edd) have been shown to be evolutionary related []. Dihydroxy-acid dehydratase catalyses the fourth step in the biosynthesis of isoleucine and valine, the dehydratation of 2,3-dihydroxy-isovaleic acid into alpha-ketoisovaleric acid. 6-Phosphogluconate dehydratase catalyses the first step in the Entner-Doudoroff pathway, the dehydratation of 6-phospho-D-gluconate into 6-phospho-2-dehydro-3-deoxy-D-gluconate. Another protein containing this signature is the Escherichia colihypothetical protein yjhG. The N-terminal part of the proteins contains a cysteine that could be involved in the binding of a 2Fe-2S iron-sulphur cluster []. Short Name:  DiOHA_6PGluconate_deHydtase
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3 Child Features

DB identifier Type Name
IPR004404 Family Dihydroxy-acid dehydratase
IPR004786 Family 6-phosphogluconate dehydratase
IPR017798 Family Dehydratase, YjhG/YagF, putative

1 Contains

DB identifier Type Name
IPR020558 Conserved_site Dihydroxy-acid/6-phosphogluconate dehydratase, conserved site

2 Cross Referencess

Identifier
PTHR21000
PF00920

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0003824 IPR000581
GO:0008152 IPR000581

2 Ontology Annotations

GO Term Gene Name
GO:0003824 IPR000581
GO:0008152 IPR000581

0 Parent Features

522 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
165632 D8QVL8 PAC:15415005 Selaginella moellendorffii 608  
404530 D8QVM6 PAC:15410980 Selaginella moellendorffii 325  
79178 D8QVM1 PAC:15422145 Selaginella moellendorffii 527  
evm.model.supercontig_59.101 PAC:16423107 Carica papaya 617  
29904.m002982 B9RWL5 PAC:16812627 Ricinus communis 615  
Cucsa.256250.1 A0A0A0L6U0 PAC:16972510 Cucumis sativus 620  
orange1.1g007192m A0A067DKU2 PAC:18119307 Citrus sinensis 613  
orange1.1g014009m A0A067DPX1 PAC:18119308 Citrus sinensis 432  
AT3G23940.1 Q9LIR4 PAC:19658715 Arabidopsis thaliana 608  
AT3G23940.2 Q9LIR4 PAC:19658716 Arabidopsis thaliana 606  
Thhalv10002451m V4LBR5 PAC:20196677 Eutrema salsugineum 605  
Ciclev10004565m V4S0R8 PAC:20791136 Citrus clementina 613  
Lus10032617 PAC:23146390 Linum usitatissimum 91  
Lus10033370 PAC:23172161 Linum usitatissimum 608  
Lus10034822 PAC:23142208 Linum usitatissimum 608  
Potri.001G051700.1 B9GMG3 PAC:27047569 Populus trichocarpa 611  
Potri.003G176600.2 PAC:26999091 Populus trichocarpa 557  
Potri.003G176600.1 B9H085 PAC:26999089 Populus trichocarpa 603  
Potri.003G176600.3 PAC:26999090 Populus trichocarpa 591  
Gorai.005G035200.1 A0A0D2R8M0 PAC:26804235 Gossypium raimondii 606  
35014 I0Z6M5 PAC:27393090 Coccomyxa subellipsoidea C-169 582  
148584 C1MJD7 PAC:27345236 Micromonas pusilla CCMP1545 575  
90156 C1DZG4 PAC:27396307 Micromonas sp RCC299 566  
34354 A4RUR5 PAC:27413431 Ostreococcus lucimarinus 567  
Thecc1EG020385t1 A0A061EST7 PAC:27451746 Theobroma cacao 606  
Thecc1EG020385t2 A0A061EJZ9 PAC:27451747 Theobroma cacao 445  
Migut.N00344.1.p A0A022QV93 PAC:28926215 Mimulus guttatus 611  
Araha.0732s0002.1.p PAC:28844879 Arabidopsis halleri 571  
Araha.11756s0258.1.p PAC:28856259 Arabidopsis halleri 617  
Cagra.0026s0003.1.p PAC:28919759 Capsella grandiflora 609  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8299945
            1624451