Protein Domain : IPR004786

Type:  Family Name:  6-phosphogluconate dehydratase
Description:  Two dehydratases, dihydroxy-acid dehydratase (gene ilvD or ILV3) and 6-phosphogluconate dehydratase (gene edd) have been shown to be evolutionary related []. Dihydroxy-aciddehydratase catalyzes the fourth step in the biosynthesis of isoleucine and valine, the dehydratation of 2,3-dihydroxy-isovaleic acid into alpha-ketoisovaleric acid. 6-Phosphogluconate dehydratase catalyzes thefirst step in the Entner-Doudoroff pathway, the dehydratation of 6-phospho-D-gluconate into 6-phospho-2-dehydro-3-deoxy-D-gluconate. Another protein containing this signature is the Escherichia colihypothetical protein yjhG. The N-terminal part of the proteins contains a cysteine that could be involved in the binding of a2Fe-2S iron-sulphur cluster [].This family defines the 6-phosphogluconate dehydratases. Short Name:  6-phosphgluc_deHydtase
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0 Child Features

1 Contains

DB identifier Type Name
IPR020558 Conserved_site Dihydroxy-acid/6-phosphogluconate dehydratase, conserved site

1 Cross References

Identifier
TIGR01196

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0004456 IPR004786
GO:0009255 IPR004786

2 Ontology Annotations

GO Term Gene Name
GO:0004456 IPR004786
GO:0009255 IPR004786

1 Parent Features

DB identifier Type Name
IPR000581 Family Dihydroxy-acid/6-phosphogluconate dehydratase

1 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brdisv1BdTR11A1041086m.p PAC:35687606 Brachypodium distachyon BdTR11a 741  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8299945
            1624451