Protein Domain : IPR003180

Type:  Family Name:  Methylpurine-DNA glycosylase (MPG)
Description:  Methylpurine-DNA glycosylase is a base excision-repair protein. It is responsible for the hydrolysis of the deoxyribose N-glycosidic bond, excising 3-methyladenine and 3-methylguanine from damaged DNA []. Its action is induced by alkylating chemotherapeutics, as well as deaminated and lipid peroxidation-induced purine adducts []. MPG without an N-terminal extension excises hypoxanthine with one-third of the efficiency of full-length MPG under similar conditions, suggesting that is function may largely be attributable to the N-terminal extension []. Short Name:  PurDNA_glycsylse
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0 Child Features

1 Contains

DB identifier Type Name
IPR011034 Domain Formyl transferase, C-terminal-like

5 Cross Referencess

Identifier
PTHR10429
PF02245
TIGR00567
G3DSA:3.10.300.10
MF_00527

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0003677 IPR003180
GO:0003905 IPR003180
GO:0006284 IPR003180

3 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR003180
GO:0003905 IPR003180
GO:0006284 IPR003180

0 Parent Features

487 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
232080 D8RQ76 PAC:15416708 Selaginella moellendorffii 238  
evm.model.supercontig_2.64 PAC:16412853 Carica papaya 224  
evm.model.supercontig_85.61 PAC:16427498 Carica papaya 260  
28582.m000324 B9SWJ1 PAC:16801146 Ricinus communis 258  
Cucsa.242540.2 PAC:16971181 Cucumis sativus 257  
Cucsa.242540.1 PAC:16971180 Cucumis sativus 281  
orange1.1g029132m A0A067FXL8 PAC:18117996 Citrus sinensis 198  
orange1.1g031868m A0A067G642 PAC:18117997 Citrus sinensis 151  
AT3G12040.1 Q39147 PAC:19664981 Arabidopsis thaliana 254  
Thhalv10021378m V4NQF9 PAC:20182247 Eutrema salsugineum 252  
Ciclev10012466m V4SVX9 PAC:20797919 Citrus clementina 269  
Ciclev10012694m V4UU46 PAC:20797920 Citrus clementina 222  
Lus10017241 PAC:23165821 Linum usitatissimum 264  
Lus10021071 PAC:23182332 Linum usitatissimum 264  
Potri.016G060000.2 B9IIB2 PAC:27013446 Populus trichocarpa 260  
Potri.016G060000.1 B9IIB2 PAC:27013447 Populus trichocarpa 260  
Gorai.012G099400.2 A0A0D2S0R2 PAC:26828275 Gossypium raimondii 221  
Gorai.012G099400.1 A0A0D2V3S9 PAC:26828274 Gossypium raimondii 260  
Thecc1EG024945t1 A0A061EYM7 PAC:27424900 Theobroma cacao 309  
Thecc1EG024945t3 A0A061F4S6 PAC:27424901 Theobroma cacao 267  
Thecc1EG024945t2 A0A061EXY3 PAC:27424902 Theobroma cacao 238  
Migut.J01851.1.p PAC:28942021 Mimulus guttatus 121  
Migut.N02098.1.p PAC:28924292 Mimulus guttatus 92  
Araha.6812s0005.1.p PAC:28850335 Arabidopsis halleri 107  
Cagra.0430s0034.2.p PAC:28917352 Capsella grandiflora 227  
Cagra.0430s0034.1.p PAC:28917351 Capsella grandiflora 252  
Cagra.4354s0028.1.p PAC:28914620 Capsella grandiflora 140  
Glyma.19G149400.2.p I1N9A7 PAC:30512254 Glycine max 273  
Glyma.19G149400.1.p I1N9A6 PAC:30512253 Glycine max 276  
Brara.A02204.1.p A0A398ARJ4 PAC:30638303 Brassica rapa FPsc 614  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            18191412
            17768096
            17716976