| Type: | Family | Name: | Glutamate--cysteine ligase, GCS2 |
| Description: | Also known as gamma-glutamylcysteine synthetase and gamma-ECS (). This enzyme catalyses the first and rate limiting step in de novo glutathione biosynthesis. Members of this family are found in archaea, bacteria and plants. May and Leaver [] discuss the possible evolutionary origins of glutamate-cysteine ligase enzymes in different organisms and suggest that it evolved independently in different eukaryotes, from an ancestral bacterial enzyme. They also state that Arabidopsis thaliana(Mouse-ear cress) gamma-glutamylcysteine synthetase is structurally unrelated to mammalian, yeast and Escherichia colihomologues. In plants, there are separate cytosolic and chloroplast forms of the enzyme. | Short Name: | GCS2 |
