Protein Domain : IPR002908

Type:  Family Name:  Frataxin/CyaY
Description:  The eukaryotic proteins in this entry include frataxin, the protein that is mutated in Friedreich's ataxia [], and related sequences. Friedreich's ataxia is a progressive neurodegenerative disorder caused by loss of function mutations in the gene encoding frataxin (FRDA). Frataxin mRNA is predominantly expressed in tissues with a high metabolic rate (including liver, kidney, brown fat and heart). Mouse and yeast frataxin homologues contain a potential N-terminal mitochondrial targeting sequence, and human frataxin has been observed to co-localise with a mitochondrial protein. Furthermore, disruption of the yeast gene has been shown to result in mitochondrial dysfunction. Friedreich's ataxia is thus believed to be a mitochondrial disease caused by a mutation in the nuclear genome (specifically, expansion of an intronic GAA triplet repeat) [, , ].The bacterial proteins in this entry are iron-sulphur cluster (FeS) metabolism CyaY proteins hmologous to eukaryotic frataxin. Partial Phylogenetic Profiling [] suggests that CyaY most likely functions as part of the ISC system for FeS cluster biosynthesis, and is supported by expermimental data in some species [, ]. Short Name:  Frataxin/CyaY
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1 Child Features

DB identifier Type Name
IPR017789 Family Frataxin

1 Contains

DB identifier Type Name
IPR020895 Conserved_site Frataxin conserved site

8 Cross Referencess

Identifier
PTHR16821
PF01491
PR00904
PS50810
TIGR03421
G3DSA:3.30.920.10
SSF55387
MF_00142

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0008199 IPR002908
GO:0016226 IPR002908

2 Ontology Annotations

GO Term Gene Name
GO:0008199 IPR002908
GO:0016226 IPR002908

0 Parent Features

550 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
103203 D8RVZ2 PAC:15407308 Selaginella moellendorffii 109  
29999.m000211 B9SZC1 PAC:16815399 Ricinus communis 200  
Cucsa.119680.1 PAC:16961017 Cucumis sativus 191  
orange1.1g036786m A0A067DJK9 PAC:18122265 Citrus sinensis 158  
orange1.1g040291m A0A067DA68 PAC:18114976 Citrus sinensis 160  
AT4G03240.1 Q9ZR07 PAC:19644849 Arabidopsis thaliana 187  
AT3G24535.1 Q3EB12 PAC:19660546 Arabidopsis thaliana 188  
Thhalv10028999m V4MZG4 PAC:20197150 Eutrema salsugineum 187  
Ciclev10016814m V4UEI0 PAC:20818838 Citrus clementina 196  
Ciclev10016813m V4UEI0 PAC:20818837 Citrus clementina 196  
Ciclev10016799m V4UEI0 PAC:20818836 Citrus clementina 196  
Lus10039728 PAC:23165230 Linum usitatissimum 188  
Lus10033750 PAC:23143270 Linum usitatissimum 183  
Potri.004G130600.1 B9H3Z0 PAC:26989268 Populus trichocarpa 1010  
Potri.013G150400.1 PAC:26993787 Populus trichocarpa 239  
Gorai.005G088600.1 A0A0D2SDA1 PAC:26803450 Gossypium raimondii 80  
Gorai.005G088600.2 A0A0D2SDA1 PAC:26803451 Gossypium raimondii 80  
Gorai.005G207400.1 A0A0D2SKT2 PAC:26806051 Gossypium raimondii 190  
19698 I0YM46 PAC:27388211 Coccomyxa subellipsoidea C-169 110  
9181 C1MW64 PAC:27341230 Micromonas pusilla CCMP1545 115  
107399 C1EBR3 PAC:27401159 Micromonas sp RCC299 190  
30187 A4RSN0 PAC:27414694 Ostreococcus lucimarinus 167  
Thecc1EG007844t1 A0A061E4I3 PAC:27462146 Theobroma cacao 184  
Thecc1EG026978t1 A0A061G7P9 PAC:27438370 Theobroma cacao 209  
Migut.F00120.1.p A0A022RZC1 PAC:28931626 Mimulus guttatus 199  
Araha.7612s0011.1.p PAC:28842649 Arabidopsis halleri 186  
Cagra.10869s0001.1.p PAC:28902529 Capsella grandiflora 148  
Cagra.2552s0004.1.p PAC:28895077 Capsella grandiflora 186  
Glyma.03G007300.1.p I1JK59 PAC:30517542 Glycine max 191  
Glyma.19G118800.1.p I1N8F6 PAC:30512794 Glycine max 191  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9241270
            8815938
            8596916
            8931268
            16930487
            16603772
            16428423