Type: | Domain | Name: | RNase L inhibitor RLI, possible metal-binding domain |
Description: | This is a possible metal-binding domain in endoribonuclease RNase L inhibitor. It is found at the N-terminal end of RNase L inhibitor proteins, adjacent to the 4Fe-4S binding domain, . Also often found adjacent to in uncharacterised proteins. The RNase L system plays a major role in the anti-viral and anti-proliferative activities of interferons [], and could possibly play a more general role in the regulation of RNA stability in mammalian cells. Inhibitory activity requires concentration-dependent association of RLI with RNase L []. | Short Name: | RNaseL-inhib_metal-bd_dom |