| Type: | Family | Name: | ABC transporter ABCE |
| Description: | This entry represents the ABCE family of ATP-binding cassette (ABC) transporters and solely comprises of the ABCE1 gene product [,,]. ABCE1 contains 2 nucleotide-binding domains (NBDs) typical of the ABC transporter protein superfamily []; however, it lacks the transmembrane domains required for membrane transport functions [,]. ABCE1 is an endoribonuclease inhibitor that interacts directly with RNase L to prevent it from binding 2-5A (5'-phosphorylated 2',5'-linked oligo- adenylates) []. RNase L plays a major role in the anti-viral and anti-proliferative activities of interferons, and its inhibition by ABCE1 occurs in a concentration-dependent manner [,]. Recently, ABCE1 has been shown to be essential for the assembly of immature HIV-1 capsids in insect cells and higher eukaryotic cell types []. ABCE1 expression is induced during HIV type I infection, and is understood to bind HIV-1 Gag (p55) polypeptides following their translation, and to promote their assembly into immature HIV-1 capsids [,,]. | Short Name: | ABCE |
| DB identifier | Type | Name |
|---|---|---|
| IPR003439 | Domain | ABC transporter-like |
| IPR017896 | Domain | 4Fe-4S ferredoxin-type, iron-sulphur binding domain |
| IPR007209 | Domain | RNase L inhibitor RLI, possible metal-binding domain |
| IPR017900 | Conserved_site | 4Fe-4S ferredoxin, iron-sulphur binding, conserved site |
| IPR017871 | Conserved_site | ABC transporter, conserved site |
