| Type: | Domain | Name: | CobW/HypB/UreG domain |
| Description: | This domain is found in HypB, a hydrogenase expression / formation protein, and urease accessory protein UreG. Both these proteins contain a P-loop nucleotide binding motif [, ]. HypB has GTPase activity and is a guanine nucleotide binding protein []. It is not known whether UreG binds GTP or some other nucleotide. Both enzymes are involved in nickel binding. HypB can store nickel and is required for nickel dependent hydrogenase expression []. UreG is required for functional incorporation of the urease nickel metallocentre []. GTP hydrolysis may required by these proteins for nickel incorporation into other nickel proteins []. Other proteins containing this domain include P47K (), a Pseudomonas chlororaphis protein needed for nitrile hydratase expression, and the cobW gene product (), which may be involved in cobalamin biosynthesis in Pseudomonas denitrificans []. | Short Name: | CobW/HypB/UreG_dom |
