Protein Domain : IPR012824

Type:  Family Name:  Cobalamin (vitamin B12) biosynthesis CobW
Description:  Cobalamin (vitamin B12) is a structurally complex cofactor, consisting of a modified tetrapyrrole with a centrally chelated cobalt. Cobalamin is usually found in one of two biologically active forms: methylcobalamin and adocobalamin. Most prokaryotes, as well as animals, have cobalamin-dependent enzymes, whereas plants and fungi do not appear to use it. In bacteria and archaea, these include methionine synthase, ribonucleotide reductase, glutamate and methylmalonyl-CoA mutases, ethanolamine ammonia lyase, and diol dehydratase []. In mammals, cobalamin is obtained through the diet, and is required for methionine synthase and methylmalonyl-CoA mutase []. There are at least two distinct cobalamin biosynthetic pathways in bacteria []:Aerobic pathway that requires oxygen and in which cobalt is inserted late in the pathway []; found in Pseudomonas denitrificansand Rhodobacter capsulatus.Anaerobic pathway in which cobalt insertion is the first committed step towards cobalamin synthesis [, ]; found in Salmonella typhimurium, Bacillus megaterium, and Propionibacterium freudenreichii subsp. shermanii. Either pathway can be divided into two parts: (1) corrin ring synthesis (differs in aerobic and anaerobic pathways) and (2) adenosylation of corrin ring, attachment of aminopropanol arm, and assembly of the nucleotide loop (common to both pathways) []. There are about 30 enzymes involved in either pathway, where those involved in the aerobic pathway are prefixed Cob and those of the anaerobic pathway Cbi. Several of these enzymes are pathway-specific: CbiD, CbiG, and CbiK are specific to the anaerobic route of S. typhimurium, whereas CobE, CobF, CobG, CobN, CobS, CobT, and CobW are unique to the aerobic pathway of P. denitrificans.This entry represents CobW proteins, which are generally found proximal to the trimeric cobaltochelatase subunit CobN, an essential protein for vitamin B12 (cobalamin) biosynthesis []. They contain a P-loop nucleotide-binding loop in the N-terminal domain and a histidine-rich region in the C-terminal portion suggesting a role in metal binding, possibly as an intermediary between the cobalt transport and chelation systems. CobW might be involved in cobalt reduction leading to cobalt(I) corrinoids. Short Name:  Cbl_biosynth_CobW
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0 Child Features

2 Contains

DB identifier Type Name
IPR011629 Domain Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal
IPR003495 Domain CobW/HypB/UreG domain

2 Cross Referencess

Identifier
PTHR13748:SF10
TIGR02475

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0009236 IPR012824

1 Ontology Annotations

GO Term Gene Name
GO:0009236 IPR012824

0 Parent Features

7 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
60235 C1EAY0 PAC:27404099 Micromonas sp RCC299 494  
Spipo18G0030600 PAC:31518645 Spirodela polyrhiza 368  
Brdisv1pangenome1005003m.p PAC:33607762 Brachypodium distachyon Pangenome 353  
Brdisv1pangenome1007205m.p PAC:33640988 Brachypodium distachyon Pangenome 356  
Brdisv1BdTR11A1049205m.p PAC:35693610 Brachypodium distachyon BdTR11a 501  
Brdisv1BdTR11A1034288m.p PAC:35677045 Brachypodium distachyon BdTR11a 353  
Brdisv1BdTR11A1042020m.p PAC:35693626 Brachypodium distachyon BdTR11a 356  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11215515
            11153269
            12869542
            17163662
            16042605
            12055304
            23922391