Protein Domain : IPR005615

Type:  Family Name:  Glutathione synthase, eukaryotic
Description:  This entry represents eukaryotic glutathione synthetase () (GSS), a homodimeric enzyme that catalyses the conversion of gamma-L-glutamyl-L-cysteine and glycine to phosphate and glutathione in the presence of ATP. This is the second step in glutathione biosynthesis, the first step being catalysed by gamma-glutamylcysteine synthetase []. In humans, defects in GSS are inherited in an autosomal recessive way and are the cause of severe metabolic acidosis, 5-oxoprolinuria, and increased rate of haemolysis and defective function of the central nervous system. Short Name:  Glutathione_synthase_euk
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0 Child Features

4 Contains

DB identifier Type Name
IPR014709 Domain Glutathione synthase domain
IPR004887 Domain Glutathione synthase, substrate-binding, eukaryotic
IPR014049 Domain Glutathione synthase, N-terminal, eukaryotic
IPR014042 Domain Glutathione synthase, alpha-helical, eukaryotic

4 Cross Referencess

Identifier
PTHR11130
PF03917
PIRSF001558
TIGR01986

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0004363 IPR005615
GO:0005524 IPR005615
GO:0006750 IPR005615

3 Ontology Annotations

GO Term Gene Name
GO:0004363 IPR005615
GO:0005524 IPR005615
GO:0006750 IPR005615

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
418834 D8S6I7 PAC:15409775 Selaginella moellendorffii 172  
121129 D8SN58 PAC:15415333 Selaginella moellendorffii 488  
123989 D8SSV1 PAC:15404958 Selaginella moellendorffii 280  
425362 D8SSV3 PAC:15404344 Selaginella moellendorffii 184  
evm.model.supercontig_48.5 PAC:16420909 Carica papaya 718  
Cucsa.163590.1 PAC:16965823 Cucumis sativus 549  
Cucsa.163590.2 PAC:16965824 Cucumis sativus 398  
orange1.1g008446m A0A067E281 PAC:18115993 Citrus sinensis 565  
orange1.1g008481m A0A067E163 PAC:18115994 Citrus sinensis 564  
Thhalv10003956m V4K412 PAC:20198998 Eutrema salsugineum 542  
Potri.005G038100.2 PAC:27030356 Populus trichocarpa 570  
Potri.005G038100.1 A0A2K2AB65 PAC:27030355 Populus trichocarpa 571  
Potri.005G038100.3 PAC:27030357 Populus trichocarpa 570  
Potri.013G026800.2 PAC:26995628 Populus trichocarpa 474  
Potri.013G026800.1 A0A2K1Y020 PAC:26995627 Populus trichocarpa 571  
Potri.013G026800.3 PAC:26995629 Populus trichocarpa 420  
Gorai.003G066300.5 A0A0D2RHW4 PAC:26797828 Gossypium raimondii 448  
Gorai.003G066300.2 A0A0D2NX98 PAC:26797825 Gossypium raimondii 549  
Gorai.003G066300.4 A0A0D2QP52 PAC:26797826 Gossypium raimondii 521  
Gorai.003G066300.3 A0A0D2RHW4 PAC:26797827 Gossypium raimondii 448  
Gorai.003G066300.1 A0A0D2QGJ2 PAC:26797824 Gossypium raimondii 553  
52209 I0ZAA4 PAC:27389297 Coccomyxa subellipsoidea C-169 486  
18089 C1MUC5 PAC:27348417 Micromonas pusilla CCMP1545 486  
108131 C1E4E9 PAC:27400724 Micromonas sp RCC299 458  
32080 A4RYM3 PAC:27418247 Ostreococcus lucimarinus 431  
Thecc1EG008925t1 A0A061E6C8 PAC:27459784 Theobroma cacao 562  
Thecc1EG008925t2 A0A061E5K4 PAC:27459785 Theobroma cacao 557  
Migut.F01584.1.p A0A022RAD4 PAC:28933298 Mimulus guttatus 543  
Glyma.03G240600.1.p I1JRF8 PAC:30518584 Glycine max 547  
Glyma.19G237700.2.p I1NC20 PAC:30512372 Glycine max 449  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            15981742