Protein Domain : IPR002811

Type:  Domain Name:  Aspartate dehydrogenase
Description:  This group contains aspartate dehydrogenases that belong to a unique class of amino acid dehydrogenases.The structure of Thermotoga maritimaTM1643 has been found to contain an N-terminal Rossmann fold domain (which binds the NAD(P)+cofactor) and a C-terminal alpha/beta domain []. This suggested that TM1643 may be a dehydrogenase with the activesite located at the interface between the two domains. Enzymatic characterisation of TM1643 revealed that it possesses NAD or NADP-dependent dehydrogenase activity toward L-aspartate but no aspartate oxidase activity[]. The product of the aspartate dehydrogenase activity is also iminoaspartate. It hasbeen suggested that two different enzymes, an oxidase and a dehydrogenase, may have evolved to catalyse the first step of NAD biosynthesis []. Members of this group share some structuralsimilarity to several other NAD(P)+-dependent oxidoreductases, including inositol 1-phosphate synthase, dihydrodipicolinate reductase, and ASA-DH [].It has been proposed that in Thermotoga maritima, TM1643 catalyses the first reaction of de novo biosynthesis of NAD from aspartate, and it produces iminoaspartate required for this pathway. The formation of an enzymecomplex between TM1643 and NadA, the next enzyme of the pathway, may allow the channeling of this unstable product directly to the NadA active site []. Short Name:  Asp_DH
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0 Child Features

0 Contains

1 Cross References

Identifier
PF01958

3 Found Ins

DB identifier Type Name
IPR011182 Family L-aspartate dehydrogenase
IPR020626 Family L-aspartate dehydrogenase, prokaryotic
IPR022487 Family L-aspartate dehydrogenase, archaeal

4 GO Annotations

GO Term Gene Name
GO:0016491 IPR002811
GO:0006742 IPR002811
GO:0019363 IPR002811
GO:0055114 IPR002811

4 Ontology Annotations

GO Term Gene Name
GO:0016491 IPR002811
GO:0006742 IPR002811
GO:0019363 IPR002811
GO:0055114 IPR002811

0 Parent Features

2 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brdisv1pangenome1009002m.p PAC:33656069 Brachypodium distachyon Pangenome 747  
Brdisv1BdTR11A1040482m.p PAC:35691372 Brachypodium distachyon BdTR11a 586  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12496312