| Type: | Domain | Name: | Homologue of theta DNA polymerase III |
| Description: | This entry represents a homologue of DNA polymerase III theta called HOT (homologue of theta) from Bacteriophage P1, as well as some bacterial hypothetical proteins. DNA polymerase III (Pol III) is the primary enzyme responsible for replication of Escherichia colichromosomal DNA, and the theta subunit appears to function in enhancing the proof-reading capability of the enzyme, especially under extreme conditions. The structure of the theta subunit consists of an irregular array of three helices that is similar to the chaperone J-domain []. Bacteriophage HOT also contains three alpha-helices, as reported for Pol III theta, but the folding topology of the two is different, which could account for the suggested greater heat stability of HOT as compared to theta []. | Short Name: | HOT |
