Protein Domain : IPR009052

Type:  Family Name:  DNA polymerase III-theta, bacterial
Description:  This entry represents the theta subunit of DNA polymerase III from bacteria, whose core structure consists of an irregular array of three helices [].DNA polymerase III (Pol III) is the primary enzyme responsible for replication of Escherichia colichromosomal DNA. The holoenzyme consists of 17 proteins and contains two core polymerases. The Pol III catalytic core has three tightly associated subunits: alpha, epsilon and theta. The alpha subunit is responsible for the DNA polymerase activity, while the epsilon subunit is the 3'-5' proofreading exonuclease. The epsilon subunit binds to both the alpha and theta subunits in the linear order alpha-epsilon-theta. The theta subunit is the smallest, and may act to enhance the proofreading activity of epsilon, especially under extreme conditions []. This entry also includes a homologue of polymerase III theta called HOT (homologue of theta) from Bacteriophage P1. HOT contains three alpha-helices, as reported for theta, but the folding topology of the two is different, which could account for the suggested greater heat stability of HOT as compared to theta []. Short Name:  DNA_pol_III_theta_bac
Paste the following link

0 Child Features

2 Contains

DB identifier Type Name
IPR011326 Domain Homologue of theta DNA polymerase III
IPR011325 Domain DNA polymerase III-theta, core, bacterial

3 Cross Referencess

Identifier
PF06440
PD057609
SSF46575

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0003677 IPR009052
GO:0003887 IPR009052
GO:0006260 IPR009052

3 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR009052
GO:0003887 IPR009052
GO:0006260 IPR009052

0 Parent Features

2 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Lus10037814 PAC:23167066 Linum usitatissimum 114  
Stapi.5676s0002.1.p PAC:39858812 Stanleya pinnata 115  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10794414
            16753031
            15576035