Protein Domain : IPR010921

Type:  Domain Name:  Trp repressor/replication initiator
Description:  The Trp repressor (TrpR) binds to at least five operators in the Escherichia coligenome, repressing gene expression. The operators at which it binds vary considerably in DNA sequence and location within the promoter; when bound to the Trp operon it recognises the sequence 5'-ACTAGT-3' and acts to prevent the initiation of transcription. The TrpR controls the trpEDCBA (trpO) operon and the genes for trpR, aroH, mtr and aroL, which are involved in the biosynthesis and uptake of the amino acid tryptophan []. The repressor binds to the operators only in the presence of L-tryptophan, thereby controlling the intracellular level of its effector; the complex also regulates Trp repressor biosynthesis by binding to its own regulatory region. TrpR acts as a dimer that is composed of identical 6-helical subunits, where four of the helices form the core of the protein and intertwine with the corresponding helices from the other subunit.The bacterial chromosomal replication initiation factor DnaA is a monomeric protein that shows structural similarity to the TrpR, except that it contains additional N-terminal helices. DnaA is a member of the AAA+ family of ATPases, and forms a large, oligomeric assembly at the replication origin site (oriC); the oligomeric complex of DnaA recognises and processes specific origin sequences in order to initiate replication in bacteria []. Short Name:  Trp_repressor/repl_initiator
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1 Child Features

DB identifier Type Name
IPR013159 Domain Chromosomal replication initiator, DnaA C-terminal

1 Contains

DB identifier Type Name
IPR018312 Conserved_site Chromosomal replication control, initiator DnaA, conserved site

1 Cross References

Identifier
SSF48295

2 Found Ins

DB identifier Type Name
IPR020591 Family Chromosomal replication control, initiator DnaA-like
IPR001957 Family Chromosomal replication control, initiator DnaA

1 GO Annotation

GO Term Gene Name
GO:0043565 IPR010921

1 Ontology Annotations

GO Term Gene Name
GO:0043565 IPR010921

0 Parent Features

129 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
evm.model.supercontig_1.356 PAC:16404295 Carica papaya 314  
evm.model.supercontig_190.32 PAC:16412140 Carica papaya 299  
32209.m000023 B9TC47 PAC:16825333 Ricinus communis 60  
29120.m000029 B9TA78 PAC:16802324 Ricinus communis 128  
28180.m000397 B9T165 PAC:16800255 Ricinus communis 591  
Cucsa.306810.1 PAC:16976115 Cucumis sativus 42  
Thecc1EG042838t1 A0A061FMZ6 PAC:27443596 Theobroma cacao 400  
Thecc1EG041901t1 A0A061H044 PAC:27428734 Theobroma cacao 392  
Thecc1EG041901t2 A0A061H044 PAC:27428735 Theobroma cacao 392  
Araha.11756s0272.1.p PAC:28856349 Arabidopsis halleri 431  
Glyma.10G057200.1.p K7LHN6 PAC:30474959 Glycine max 59  
Glyma.13G143700.1.p K7LZR1 PAC:30503483 Glycine max 58  
Glyma.19G183200.1.p K7MZ23 PAC:30512565 Glycine max 63  
Brara.D02248.1.p A0A397ZNP3 PAC:30621041 Brassica rapa FPsc 53  
Medtr7g101850.1 G7L3V3 PAC:31081260 Medicago truncatula 64  
Traes_3AL_5A56DED3C.1 PAC:31749740 Triticum aestivum 337  
Traes_3AL_5A56DED3C.2 PAC:31749741 Triticum aestivum 337  
Traes_3B_26920CDA2.1 PAC:31766863 Triticum aestivum 395  
Traes_3B_26920CDA2.2 PAC:31766864 Triticum aestivum 332  
Traes_3DL_2108D45DE.1 PAC:31836067 Triticum aestivum 165  
Traes_3DL_2108D45DE.3 PAC:31836066 Triticum aestivum 165  
Traes_3DL_2108D45DE.4 PAC:31836069 Triticum aestivum 159  
Traes_3DL_2108D45DE.2 PAC:31836068 Triticum aestivum 165  
Prupe.6G084600.1.p M5VYK8 PAC:32088822 Prunus persica 394  
Prupe.2G229800.1.p M5XD65 PAC:32076128 Prunus persica 345  
GSMUA_Achr6P34300_001 PAC:32320447 Musa acuminata 109  
Pp3s32_260V3.1.p PAC:32948413 Physcomitrium patens 2208  
Pp3s405_30V3.1.p PAC:32983517 Physcomitrium patens 225  
Pp3c10_20230V3.2.p A9SDA3 PAC:32900959 Physcomitrium patens 296  
Pp3c10_20230V3.1.p A9SDA3 PAC:32900958 Physcomitrium patens 296  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12475235
            12234917