Protein Domain : IPR015224

Type:  Domain Name:  Talin, central
Description:  This domain adopts a structure consisting of five alpha helices that fold into a bundle. It contains a Vinculin binding site (VBS) composed of a hydrophobic surface spanning five turns of helix four. Activation of the VBS causes subsequent recruitment of Vinculin, which enables maturation of small integrin/talin complexes into more stable adhesions. Formation of the complex between VBS and Vinculin requires prior unfolding of this middle domain: once released from the talin hydrophobic core, the VBS helix is then available to induce the 'bundle conversion' conformational change within the vinculin head domain thereby displacing the intramolecular interaction with the vinculin tail, allowing vinculin to bind actin []. Short Name:  Talin_cent
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0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF09141
G3DSA:1.20.1420.10
SSF109880

1 Found In

DB identifier Type Name
IPR015710 Family Talin-1

4 GO Annotations

GO Term Gene Name
GO:0005200 IPR015224
GO:0007016 IPR015224
GO:0001726 IPR015224
GO:0005925 IPR015224

4 Ontology Annotations

GO Term Gene Name
GO:0005200 IPR015224
GO:0007016 IPR015224
GO:0001726 IPR015224
GO:0005925 IPR015224

0 Parent Features

163 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
evm.model.supercontig_12.166 PAC:16406710 Carica papaya 377  
Thhalv10004373m V4KWV5 PAC:20198151 Eutrema salsugineum 390  
Lus10034970 PAC:23181350 Linum usitatissimum 270  
Potri.001G071400.1 A0A2K2BTN5 PAC:27044345 Populus trichocarpa 479  
Gorai.001G120300.2 A0A0D2QGD3 PAC:26824849 Gossypium raimondii 125  
28610 A4RQC0 PAC:27417677 Ostreococcus lucimarinus 617  
Migut.O00950.1.p PAC:28929979 Mimulus guttatus 235  
Araha.7188s0002.1.p PAC:28850672 Arabidopsis halleri 516  
Glyma.20G123200.2.p I1NFS0 PAC:30520713 Glycine max 306  
Glyma.20G123200.1.p A0A0R0EAF6 PAC:30520712 Glycine max 368  
Brara.B03668.1.p A0A398AFZ8 PAC:30610048 Brassica rapa FPsc 517  
Medtr3g098630.1 G7J3A1 PAC:31059673 Medicago truncatula 76  
Traes_6DL_C318F67AD.1 PAC:31860712 Triticum aestivum 68  
Eucgr.K00649.1.p A0A058ZZD7 PAC:32068347 Eucalyptus grandis 367  
Prupe.4G208500.1.p M5WTJ5 PAC:32091655 Prunus persica 379  
Pahal.A03714.2 PAC:32525213 Panicum hallii 624  
Pahal.A03714.1 A0A2T8KY72 PAC:32525212 Panicum hallii 639  
Mapoly0029s0129.2.p A0A2R6X943 PAC:33014736 Marchantia polymorpha 723  
Mapoly0029s0129.1.p A0A2R6X953 PAC:33014735 Marchantia polymorpha 746  
Aco030943.1 PAC:33041921 Ananas comosus 150  
Aqcoe1G110200.1.p A0A2G5EG65 PAC:33081366 Aquilegia coerulea 332  
Zosma1g01080.1 A0A0K9PPI9 PAC:33179088 Zostera marina 217  
Brdisv1Gaz-81009811m.p PAC:33809103 Brachypodium distachyon Gaz-8 165  
Brdisv1Gaz-81009812m.p PAC:33809102 Brachypodium distachyon Gaz-8 230  
Brdisv1ABR81012153m.p PAC:34560998 Brachypodium distachyon ABR8 442  
Tp57577_TGAC_v2_mRNA36584 PAC:35991273 Trifolium pratense 419  
Oropetium_20150105_03716A PAC:35995312 Oropetium thomaeum 264  
Solyc11g011830.1.1 PAC:36153252 Solanum lycopersicum 83  
AUR62012103-RA PAC:36280458 Chenopodium quinoa 414  
Zm00008a031733_P01 PAC:37191965 Zea mays PH207 157  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            15272303