| Type: | Family | Name: | Talin-1 |
| Description: | Talin is a cytoskeletal protein that interacts with integrins and lipids. It forms an antiparallel homodimer with an N-terminal globular head and a larger C-terminal rod []. The head domain contains a FERM (4.1, ezrin, radixin, moesin) domain, which has been implicated in both integrin and actin-binding. Binding of integrin beta cytoplasmic tails to the FERM domain has been found to induce integrin activation []. The rod domain also appears to mediate binding to both actin and integrins []. The C-terminal rod contains an I/LWEQ domain. It has been shown that the I/LWEQ domains from mouse talin and yeast Sla2p interact with F-actin []. The domain has four conserved blocks, the name of the domain is derived from the initial conserved amino acid of each of the four blocks [].In vivo, talin has been shown to play a critical role in the formation of cell adhesions and regulation of integrin signalling in numerous species []. Talin localises to some neuromuscular junction and sites of cell-cell adhesions, as well as to focal adhesions, sites of attachment to the substratum. Filopodin, a homologue of talin, was identified in the slime mold Dictyostelium discoideum(Slime mold).This entry represents talin-1. | Short Name: | Talin-1 |
| DB identifier | Type | Name |
|---|---|---|
| IPR011993 | Domain | Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) |
| IPR019748 | Domain | FERM central domain |
| IPR018979 | Domain | FERM, N-terminal |
| IPR000299 | Domain | FERM domain |
| IPR019749 | Domain | Band 4.1 domain |
| IPR015224 | Domain | Talin, central |
| IPR002558 | Domain | I/LWEQ domain |
| IPR015009 | Domain | Vinculin-binding site-containing domain |
