Protein Domain : IPR011993

Type:  Domain Name:  Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Description:  Pleckstrin homology (PH) domains are small modular domains that occur in a large variety of signalling proteins, where they serve as simple targeting domains that bind lipids [, , ]. PH domains have a partly opened beta-barrel topology that is capped by an alpha helix. The structure of PH domains is similar to the phosphotyrosine-binding domain (PTB) found in IRS-1 (insulin receptor substrate 1), Shc adaptor and Numb; to the Ran-binding domain, found in Nup nuclear pore complex and Ranbp1; to the Enabled/VASP homology domain 1 (EVH1 domain), found in Enabled, VASP (vasodilator-stimulated phosphoprotein), Homer and WASP actin regulatory protein; to the third domain of FERM, found in moesin, radixin, ezrin, merlin and talin; and to the PH-like domain of neurobeachin.This entry recognises PH domains and other structurally related domains. Short Name:  PH/PTB_dom
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7 Child Features

DB identifier Type Name
IPR013876 Domain TFIIH p62 subunit, N-terminal
IPR001849 Domain Pleckstrin homology domain
IPR000156 Domain Ran binding domain
IPR000697 Domain WH1/EVH1 domain
IPR006020 Domain PTB/PI domain
IPR018980 Domain FERM, C-terminal PH-like domain
IPR002404 Domain IRS-type PTB domain

2 Contains

DB identifier Type Name
IPR001562 Conserved_site Zinc finger, Btk motif
IPR013625 Domain Tensin phosphotyrosine-binding domain

1 Cross References

Identifier
G3DSA:2.30.29.30

16 Found Ins

DB identifier Type Name
IPR000299 Domain FERM domain
IPR015767 Family Rho GTPase activating protein
IPR012151 Family Protein-tyrosine phosphatase, non-receptor type-3, -4
IPR014392 Family Protein-tyrosine phosphatase, non-receptor type-14, -21
IPR021187 Family Band 4.1 protein
IPR000798 Family Ezrin/radixin/moesin-like
IPR011174 Family Ezrin/radixin/moesin
IPR012153 Family Tyrosine-protein phosphatase non-receptor type 13
IPR015710 Family Talin-1
IPR015711 Family Talin-2
IPR016343 Family Spectrin, beta subunit
IPR015788 Family Moesin/ezrin/radixin homologue 2
IPR016279 Family Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma
IPR016609 Family Uncharacterised protein Opy1
IPR015727 Family Protein kinase C mu-related
IPR017405 Family Citron Rho-interacting kinase

0 GO Annotation

0 Ontology Annotations

0 Parent Features

45262 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
171046 D8RFP1 PAC:15405828 Selaginella moellendorffii 915  
267397 D8RGF1 PAC:15410653 Selaginella moellendorffii 410  
431566 D8TD27 PAC:15401470 Selaginella moellendorffii 250  
441545 D8RKK3 PAC:15408575 Selaginella moellendorffii 251  
165523 D8QV06 PAC:15414247 Selaginella moellendorffii 216  
165360 D8QU73 PAC:15412737 Selaginella moellendorffii 216  
404739 D8QW87 PAC:15412503 Selaginella moellendorffii 775  
438325 D8QW50 PAC:15420341 Selaginella moellendorffii 752  
77895 D8QVU2 PAC:15421702 Selaginella moellendorffii 203  
414494 D8RSY6 PAC:15417510 Selaginella moellendorffii 824  
165919 D8QXV8 PAC:15417204 Selaginella moellendorffii 853  
79570 D8QXT3 PAC:15402928 Selaginella moellendorffii 247  
104789 D8RZ35 PAC:15414456 Selaginella moellendorffii 140  
443866 D8S512 PAC:15416855 Selaginella moellendorffii 494  
444026 D8S6P2 PAC:15413592 Selaginella moellendorffii 491  
81087 D8QYV2 PAC:15405262 Selaginella moellendorffii 119  
418943 D8S7A9 PAC:15410633 Selaginella moellendorffii 244  
179756 D8SHG4 PAC:15412360 Selaginella moellendorffii 527  
234346 D8SK59 PAC:15402388 Selaginella moellendorffii 514  
439298 D8R3E7 PAC:15422626 Selaginella moellendorffii 715  
439664 D8R4U7 PAC:15403248 Selaginella moellendorffii 825  
85701 D8R6K4 PAC:15422051 Selaginella moellendorffii 188  
86277 D8R517 PAC:15421344 Selaginella moellendorffii 192  
164063 D8QMJ5 PAC:15407392 Selaginella moellendorffii 489  
236037 D8T4G5 PAC:15405927 Selaginella moellendorffii 650  
89070 D8RB45 PAC:15406334 Selaginella moellendorffii 756  
89681 D8RAV4 PAC:15411041 Selaginella moellendorffii 430  
439923 D8R8B6 PAC:15405465 Selaginella moellendorffii 1457  
437478 D8QR58 PAC:15418311 Selaginella moellendorffii 1780  
77824 D8QSV0 PAC:15421530 Selaginella moellendorffii 896  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            14594214
            12694559
            21119626