Protein Domain : IPR011174

Type:  Family Name:  Ezrin/radixin/moesin
Description:  This group represents an ezrin/radixin/moesin. The ERM family consists of three closely-related proteins, ezrin, radixin and moesin [].Ezrin was first identified as a constituent of microvilli [], radixin as a barbed, end-capping actin-modulating protein from isolated junctional fractions [], and moesin as a heparinbinding protein []. A tumour suppressor molecule responsible for neurofibromatosis type 2 (NF2)is highly similar to ERM proteins and has been designated merlin (moesin-ezrin-radixin-like protein). ERM molecules contain 3 domains, an N-terminal globular domain; an extended alpha-helical domain; and acharged C-terminal domain []. Ezrin, radixin and merlin also contain a polyproline region betweenthe helical and C-terminal domains. The N-terminal domain is highly conserved, and is also found in merlin, band 4.1 proteins and members of the band 4.1 superfamily. ERM proteins crosslink actin filaments withplasma membranes. They co-localise with CD44 at actin filament-plasma membrane interaction sites, associating with CD44 via their N-terminal domains and with actin filaments via their C-terminal domains[]. Short Name:  ERM
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1 Child Features

DB identifier Type Name
IPR015788 Family Moesin/ezrin/radixin homologue 2

9 Contains

DB identifier Type Name
IPR011993 Domain Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
IPR019748 Domain FERM central domain
IPR018979 Domain FERM, N-terminal
IPR000299 Domain FERM domain
IPR019749 Domain Band 4.1 domain
IPR008954 Domain Moesin tail domain
IPR011259 Domain Ezrin/radixin/moesin, C-terminal
IPR019747 Conserved_site FERM conserved site
IPR018980 Domain FERM, C-terminal PH-like domain

1 Cross References

Identifier
PIRSF002305

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0008092 IPR011174
GO:0005737 IPR011174
GO:0019898 IPR011174

3 Ontology Annotations

GO Term Gene Name
GO:0008092 IPR011174
GO:0005737 IPR011174
GO:0019898 IPR011174

1 Parent Features

DB identifier Type Name
IPR000798 Family Ezrin/radixin/moesin-like

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3046603
            6885906
            2500445
            9048483