| Type: | Family | Name: | Moesin/ezrin/radixin homologue 2 |
| Description: | This entry represents the moesin/ezrin/radixin homologue 2 (EMR2, also known as Mer). It is a regulator of the Hippo/SWH (Sav/Wts/Hpo) signalling pathway, a signalling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. EMR2 acts synergistically along with Ex and Kibra to regulate the Hippo signalling pathway [, ]. | Short Name: | EMR2 |
| DB identifier | Type | Name |
|---|---|---|
| IPR014352 | Domain | FERM/acyl-CoA-binding protein, 3-helical bundle |
| IPR011993 | Domain | Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) |
| IPR019748 | Domain | FERM central domain |
| IPR000299 | Domain | FERM domain |
| IPR019749 | Domain | Band 4.1 domain |
| IPR008954 | Domain | Moesin tail domain |
| IPR011259 | Domain | Ezrin/radixin/moesin, C-terminal |
| IPR019747 | Conserved_site | FERM conserved site |
| IPR018980 | Domain | FERM, C-terminal PH-like domain |
