Protein Domain : IPR019749

Type:  Domain Name:  Band 4.1 domain
Description:  The FERM domain (F for 4.1 protein, E for ezrin, R for radixin and M for moesin) is a widespread protein module involved in localising proteins to the plasma membrane []. FERM domains are found in a number of cytoskeletal-associated proteins that associate with various proteins at the interface between the plasma membrane and the cytoskeleton. The FERM domain is located at the N terminus of the majority of FERM-containing proteins [, ], which includes: Band 4.1, which links the spectrin-actin cytoskeleton of erythrocytes to the plasma membrane.Ezrin, a component of the undercoat of the microvilli plasma membrane.Moesin, which is probably involved in binding major cytoskeletal structures to the plasma membrane.Radixin, which is involved in the binding of the barbed end of actin filaments to the plasma membrane in the undercoat of the cell- to-cell adherens junction.Talin, a cytoskeletal protein concentrated in regions of cell-substratum contact and, in lymphocytes, of cell-cell contacts.Filopodin, a slime mold protein that binds actin and which is involved in the control of cell motility and chemotaxis.Merlin (or schwannomin).Protein NBL4.Unconventional myosins X, VIIa and XV, which are mutated in congenital deafness.Focal-adhesion kinases (FAKs), cytoplasmic protein tyrosine kinases involved in signalling through integrins.Janus tyrosine kinases (JAKs), cytoplasmic tyrosine kinases that are non-covalently associated with the cytoplasmic tails of receptors for cytokines or polypeptidic hormones.Non-receptor tyrosine-protein kinase TYK2.Protein-tyrosine phosphatases PTPN3 and PTPN4, enzyme that appear to act at junctions between the membrane and the cytoskeleton.Protein-tyrosine phosphatases PTPN14 and PTP-D1, PTP-RL10 and PTP2E.Caenorhabditis elegansprotein phosphatase ptp-1.Ezrin, moesin, and radixin are highly related proteins (ERM protein family), but the other proteins in which the FERM domain is found do not share any region of similarity outside of this domain. ERM proteins are made of three domains, the FERM domain, a central helical domain and a C-terminal tail domain, which binds F-actin. The amino-acid sequence of the FERM domain is highly conserved among ERM proteins and is responsible for membrane association by direct binding to the cytoplasmic domain or tail of integral membrane proteins. ERM proteins are regulated by an intramolecular association of the FERM and C-terminal tail domains that masks their binding sites for other molecules. For cytoskeleton-membrane cross-linking, the dormant molecules becomes activated and the FERM domain attaches to the membrane by binding specific membrane proteins, while the last 34 residues of the tail bind actin filaments. Aside from binding to membranes, the activated FERM domain of ERM proteins can also bind the guanine nucleotide dissociation inhibitor of Rho GTPase (RhoDGI), which suggests that in addition to functioning as a cross-linker, ERM proteins may influence Rho signalling pathways. The crystal structure of the FERM domain reveals that it is composed of three structural modules (F1, F2, and F3) that together form a compact clover-shaped structure [].The FERM domain has also been called the amino-terminal domain, the 30kDa domain, 4.1N30, the membrane-cytoskeletal-linking domain, the ERM-like domain, the ezrin-like domain of the band 4.1 superfamily, the conserved N-terminal region, and the membrane attachment domain []. Short Name:  Band_41_domain
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0 Child Features

4 Contains

DB identifier Type Name
IPR014352 Domain FERM/acyl-CoA-binding protein, 3-helical bundle
IPR019748 Domain FERM central domain
IPR018979 Domain FERM, N-terminal
IPR019747 Conserved_site FERM conserved site

2 Cross Referencess

Identifier
PR00935
SM00295

13 Found Ins

DB identifier Type Name
IPR000299 Domain FERM domain
IPR016251 Family Tyrosine-protein kinase, non-receptor Jak/Tyk2
IPR012151 Family Protein-tyrosine phosphatase, non-receptor type-3, -4
IPR014392 Family Protein-tyrosine phosphatase, non-receptor type-14, -21
IPR021187 Family Band 4.1 protein
IPR011174 Family Ezrin/radixin/moesin
IPR012153 Family Tyrosine-protein phosphatase non-receptor type 13
IPR015710 Family Talin-1
IPR015711 Family Talin-2
IPR015788 Family Moesin/ezrin/radixin homologue 2
IPR020693 Family Tyrosine-protein kinase, non-receptor Jak2
IPR020775 Family Tyrosine-protein kinase, non-receptor Jak3
IPR020776 Family Tyrosine-protein kinase, non-receptor Jak1

0 GO Annotation

0 Ontology Annotations

0 Parent Features

284 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
414494 D8RSY6 PAC:15417510 Selaginella moellendorffii 824  
Cucsa.323300.1 PAC:16977928 Cucumis sativus 1128  
AT5G65930.1 Q9FHN8 PAC:19669416 Arabidopsis thaliana 1259  
AT5G65930.3 F4JXM5 PAC:19669414 Arabidopsis thaliana 1266  
AT5G65930.2 Q9FHN8 PAC:19669415 Arabidopsis thaliana 1260  
Thhalv10003532m V4JZT5 PAC:20199786 Eutrema salsugineum 1229  
Thhalv10003527m V4MIA8 PAC:20199785 Eutrema salsugineum 1262  
45791 C1N0A3 PAC:27340150 Micromonas pusilla CCMP1545 1084  
Araha.15174s0002.1.p PAC:28842973 Arabidopsis halleri 1261  
Cagra.10427s0001.1.p PAC:28917474 Capsella grandiflora 1261  
Brara.B03983.1.p A0A398AH02 PAC:30611040 Brassica rapa FPsc 1251  
Brara.I00936.1.p A0A397XS97 PAC:30644353 Brassica rapa FPsc 662  
Bostr.0568s0001.1.p PAC:30669082 Boechera stricta 1261  
SapurV1A.0047s0570.1.p PAC:31395697 Salix purpurea 1269  
SapurV1A.0047s0570.2.p PAC:31395698 Salix purpurea 1263  
Pp3c1_18911V3.2.p PAC:32967825 Physcomitrium patens 464  
Mapoly0090s0045.2.p A0A2R6WHI9 PAC:33014317 Marchantia polymorpha 666  
Mapoly0090s0045.1.p A0A2R6WHI9 PAC:33014316 Marchantia polymorpha 666  
AL8G45710.t1 PAC:35948141 Arabidopsis lyrata 1261  
AUR62016257-RA PAC:36290109 Chenopodium quinoa 1280  
AUR62003324-RA PAC:36301879 Chenopodium quinoa 1542  
Bol019312 PAC:37349908 Brassica oleracea capitata 1265  
AT5G65930.1 Q9FHN8 PAC:37418836 Arabidopsis thaliana 1259  
AT5G65930.3 F4JXM5 PAC:37418834 Arabidopsis thaliana 1266  
AT5G65930.2 Q9FHN8 PAC:37418835 Arabidopsis thaliana 1260  
Anaoc.1342s0003.1.p PAC:37486227 Anacardium occidentale 1173  
HORVU2Hr1G108840.5 PAC:38350180 Hordeum vulgare 984  
Lsat_1_v5_gn_2_72800.1 A0A2J6L5Z1 PAC:38960246 Lactuca sativa 1268  
Caamp.0436s0044.1.p PAC:39059831 Caulanthus amplexicaulis 1263  
Caamp.0033s0491.1.p PAC:39056903 Caulanthus amplexicaulis 1220  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9757824
            10847681
            10970839