1 Parent Features
| DB identifier | Type | Name |
|---|---|---|
| IPR011993 | Domain | Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) |
| Type: | Domain | Name: | WH1/EVH1 domain |
| Description: | The EVH1 (WH1, RanBP1-WASP) domain is found in multi-domain proteins implicated in a diverse range of signalling, nuclear transport and cytoskeletal events. This domain of around 115 amino acids is present in species ranging from yeast to mammals. Many EVH1-containing proteins associate with actin-based structures and play a role in cytoskeletal organisation. EVH1 domains recognise and bind the proline-rich motif FPPPP with low-affinity, further interactions then form between flanking residues [, ].WASP family proteins contain a EVH1 (WH1) in their N-terminals which bind proline-rich sequences in the WASP interacting protein. Proteins of the RanBP1 family contain a WH1 domain in their N-terminal region, which seems to bind a different sequence motif present in the C-terminal part of RanGTP protein [,]. Tertiary structure of the WH1 domain of the Mena protein revealed structure similarities with the pleckstrin homology (PH) domain. The overall fold consists of a compact parallel beta-sandwich, closed along one edge by a long alpha-helix. A highly conserved cluster of three surface-exposed aromatic side-chains forms the recognition site for the molecules target ligands. []. | Short Name: | WH1/EVH1_dom |
| DB identifier | Type | Name |
|---|---|---|
| IPR011993 | Domain | Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) |
