Protein Domain : IPR009400

Type:  Family Name:  TFIIH subunit TTDA/Tfb5
Description:  This entry represents TTDA/Tfb5 subunit of TFIIH basal transcription factor complex. These proteins have a structural motif consisting of a 2-layer sandwich structure with an alpha/beta plait topology. Nucleotide excision repair is a major pathway for repairing UV light-induced DNA damage in most organisms.Transcription/repair factor IIH (TFIIH) is essential for RNA polymerase II transcription and nucleotide excision repair. The TFIIH multiprotein complex consists of a 7-subunit core (XPB, p62, p52, p44, p34, and TTDA) that is associated with a 3-subunit CDK-activating kinase module (MAT1, cyclin H and Cdk7) [].In humans, defects in TTDA cause the trichothiodystrophy photosensitive (TTDP), an autosomal recessive disease characterised by sulfur-deficient brittle hair and nails, ichthyosis, mental retardation, impaired sexual development, abnormal facies and cutaneous photosensitivity correlated with a nucleotide excision repair (NER) defect []. Short Name:  TFIIH_TTDA/Tfb5
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0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF06331
G3DSA:3.30.70.1220
SSF142897

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0006289 IPR009400
GO:0006355 IPR009400
GO:0000439 IPR009400

3 Ontology Annotations

GO Term Gene Name
GO:0006289 IPR009400
GO:0006355 IPR009400
GO:0000439 IPR009400

0 Parent Features

570 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
evm.model.supercontig_29.74 PAC:16416285 Carica papaya 70  
Cucsa.320370.1 A0A0A0L4F5 PAC:16977340 Cucumis sativus 70  
orange1.1g046733m A0A067G7N9 PAC:18105682 Citrus sinensis 106  
orange1.1g035227m A0A067F8T9 PAC:18120281 Citrus sinensis 70  
orange1.1g035190m A0A067F8T9 PAC:18120279 Citrus sinensis 70  
orange1.1g035220m A0A067F8T9 PAC:18120280 Citrus sinensis 70  
orange1.1g029604m A0A067H3W2 PAC:18137633 Citrus sinensis 191  
AT1G12400.1 Q6NNM0 PAC:19656625 Arabidopsis thaliana 71  
AT1G62886.1 B3H572 PAC:19650325 Arabidopsis thaliana 72  
Thhalv10029420m V4LEJ1 PAC:20197293 Eutrema salsugineum 72  
Thhalv10009271m V4KZY1 PAC:20188322 Eutrema salsugineum 70  
Thhalv10023898m V4JUR2 PAC:20201371 Eutrema salsugineum 82  
Ciclev10024015m V4TJW9 PAC:20807926 Citrus clementina 130  
Ciclev10022401m V4VYP8 PAC:20806871 Citrus clementina 191  
Ciclev10006411m V4RGV8 PAC:20789735 Citrus clementina 102  
Lus10000383 PAC:23159284 Linum usitatissimum 70  
Lus10007001 PAC:23168969 Linum usitatissimum 70  
Lus10006998 PAC:23168943 Linum usitatissimum 70  
Potri.009G138800.1 B9HR23 PAC:26987935 Populus trichocarpa 70  
Potri.001G116000.3 B9N3L1 PAC:27043121 Populus trichocarpa 70  
Potri.001G116000.1 B9N3L1 PAC:27043120 Populus trichocarpa 70  
Potri.001G116000.2 B9N3L1 PAC:27043119 Populus trichocarpa 70  
Potri.001G116000.4 B9N3L1 PAC:27043118 Populus trichocarpa 70  
Gorai.008G240500.2 A0A0D2Q0M7 PAC:26818834 Gossypium raimondii 70  
Gorai.008G240500.1 A0A0D2Q0M7 PAC:26818835 Gossypium raimondii 70  
Gorai.009G273800.3 A0A0D2QP31 PAC:26768956 Gossypium raimondii 299  
Gorai.009G273800.4 A0A0D2S975 PAC:26768957 Gossypium raimondii 255  
150403 PAC:27343176 Micromonas pusilla CCMP1545 62  
79527 C1E0T4 PAC:27398335 Micromonas sp RCC299 75  
27487 A4S7H4 PAC:27419785 Ostreococcus lucimarinus 75  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            21592869
            15220921