Protein Domain : IPR008832

Type:  Family Name:  Signal recognition particle, SRP9 subunit
Description:  The signal recognition particle (SRP) is a multimeric protein, which along with its conjugate receptor (SR), is involved in targeting secretory proteins to the rough endoplasmic reticulum (RER) membrane in eukaryotes, or to the plasma membrane in prokaryotes [, ]. SRP recognises the signal sequence of the nascent polypeptide on the ribosome. In eukaryotes this retards its elongation until SRP docks the ribosome-polypeptide complex to the RER membrane via the SR receptor []. Eukaryotic SRP consists of six polypeptides (SRP9, SRP14, SRP19, SRP54, SRP68 and SRP72) and a single 300 nucleotide 7S RNA molecule. The RNA component catalyses the interaction of SRP with its SR receptor []. In higher eukaryotes, the SRP complex consists of the Alu domain and the S domain linked by the SRP RNA. The Alu domain consists of a heterodimer of SRP9 and SRP14 bound to the 5' and 3' terminal sequences of SRP RNA. This domain is necessary for retarding the elongation of the nascent polypeptide chain, which gives SRP time to dock the ribosome-polypeptide complex to the RER membrane. In archaea, the SRP complex contains 7S RNA like its eukaryotic counterpart, yet only includes two of the six protein subunits found in the eukarytic complex: SRP19 and SRP54 [].This entry represents the 9 kDa SRP9 component. Both SRP9 and SRP14 have the same (beta)-alpha-beta(3)-alpha fold. The heterodimer has pseudo two-fold symmetry and is saddle-like, consisting of a curved six-stranded beta-sheet that has four helices packed on the convex side and an exposed concave surface lined with positively charged residues. The SRP9/SRP14 heterodimer is essential for SRP RNA binding, mediating the pausing of synthesis of ribosome associated nascent polypeptides that have been engaged by the targeting domain of SRP []. Short Name:  Signal_recog_particle_SRP9
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PTHR12834
PIRSF017029

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0008312 IPR008832
GO:0006614 IPR008832
GO:0045900 IPR008832
GO:0048500 IPR008832

4 Ontology Annotations

GO Term Gene Name
GO:0008312 IPR008832
GO:0006614 IPR008832
GO:0045900 IPR008832
GO:0048500 IPR008832

0 Parent Features

481 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
evm.model.supercontig_52.142 PAC:16422001 Carica papaya 103  
29883.m002007 B9S4T7 PAC:16812094 Ricinus communis 103  
29883.m002022 B9S4V2 PAC:16812109 Ricinus communis 103  
Cucsa.168380.2 A0A0A0LIQ2 PAC:16966327 Cucumis sativus 103  
Cucsa.168380.3 PAC:16966328 Cucumis sativus 87  
Cucsa.168380.1 A0A0A0LIQ2 PAC:16966326 Cucumis sativus 103  
orange1.1g034131m PAC:18093161 Citrus sinensis 103  
AT3G49100.1 Q9SMU7 PAC:19660182 Arabidopsis thaliana 103  
Thhalv10010849m V4LT22 PAC:20207067 Eutrema salsugineum 103  
Ciclev10023004m V4TZI0 PAC:20808618 Citrus clementina 103  
Ciclev10023009m V4TZI0 PAC:20808617 Citrus clementina 103  
Lus10018775 PAC:23176252 Linum usitatissimum 148  
Lus10024862 PAC:23178844 Linum usitatissimum 139  
Potri.002G043600.2 PAC:27021329 Populus trichocarpa 75  
Potri.002G043600.1 B9GS60 PAC:27021328 Populus trichocarpa 103  
Potri.005G219400.3 PAC:27027439 Populus trichocarpa 75  
Potri.005G219400.2 PAC:27027438 Populus trichocarpa 80  
Potri.005G219400.1 A9P8V6 PAC:27027437 Populus trichocarpa 103  
Gorai.004G219200.1 A0A0D2S3R8 PAC:26775207 Gossypium raimondii 103  
Gorai.004G219200.2 A0A0D2R8L6 PAC:26775208 Gossypium raimondii 75  
Gorai.007G142700.2 A0A0D2T640 PAC:26784397 Gossypium raimondii 74  
Gorai.007G142700.1 A0A0D2S406 PAC:26784396 Gossypium raimondii 102  
9523 I0Z8A5 PAC:27393425 Coccomyxa subellipsoidea C-169 77  
202926 PAC:27342984 Micromonas pusilla CCMP1545 84  
Thecc1EG004191t1 A0A061DQ63 PAC:27433035 Theobroma cacao 103  
Migut.D00388.1.p A0A022S3K2 PAC:28927578 Mimulus guttatus 103  
Migut.N02186.1.p A0A022PQZ8 PAC:28923375 Mimulus guttatus 103  
Araha.17616s0002.1.p PAC:28838678 Arabidopsis halleri 103  
Cagra.0645s0015.1.p PAC:28896918 Capsella grandiflora 103  
Glyma.08G346000.1.p I1KZ11 PAC:30538513 Glycine max 103  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            16469117
            17622352
            17507650
            12364595
            12605305
            7730321