4 GO Annotations
| GO Term | Gene Name |
|---|---|
| GO:0008750 | IPR012136 |
| GO:0050661 | IPR012136 |
| GO:0055114 | IPR012136 |
| GO:0016021 | IPR012136 |
4 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0008750 | IPR012136 |
| GO:0050661 | IPR012136 |
| GO:0055114 | IPR012136 |
| GO:0016021 | IPR012136 |
| Type: | Family | Name: | NADP transhydrogenase, beta subunit |
| Description: | NAD(P) transhydrogenase catalyses the transfer of reducing equivalents between NAD(H) and NADP(H), coupled to the translocation of protons across a membrane []. It is an integral membrane protein found in most organisms except for yeasts, plants and some bacterial species. In bacterial species it is located in the cytoplasmic membrane, while in mitochondria it is located in the inner membrane. Under most physiological conditions this enzyme synthesises NADPH, driven by consumption of the proton electrochemical gradient. The resulting NADPH is subsequently used for biosynthetic reactions or the reduction of glutathione.The global structure of this enzyme is similar in all organisms, consisting of three distinct domains, though the polypeptide composition can vary. Domain I binds NAD(+)/NADH, domain II is a hydrophobic membrane-spanning domain, and domain III binds NADP(+)/NADPH. Domain I is composed of two subdomains, both of which form a Rossman fold, while domain III consists of a single Rossman fold where the NADP(+) is flipped relative to the normal orientation of bound nucleotides within the Rossman fold [, , ]. Several residues within these domains are thought to make functionally important interdomain contacts for hydride transfer between these domains []. Proton translocation occurs through domain II and is thought to induce conformational changes which are transmitted across domain III to the site of hydride transfer between domains I and III.This entry represents the beta subunit found in bacterial two-subunit NADP(H) transhydrogenases. This subunit forms domain III and part of the transmembrane domain II. | Short Name: | NADH_DH_b |
| GO Term | Gene Name |
|---|---|
| GO:0008750 | IPR012136 |
| GO:0050661 | IPR012136 |
| GO:0055114 | IPR012136 |
| GO:0016021 | IPR012136 |
| GO Term | Gene Name |
|---|---|
| GO:0008750 | IPR012136 |
| GO:0050661 | IPR012136 |
| GO:0055114 | IPR012136 |
| GO:0016021 | IPR012136 |
