Protein Domain : IPR030004

Type:  Family Name:  Gelsolin
Description:  Gelsolin is an actin-modulating protein that severs F-actin, caps the barbed ends of actin filaments preventing monomer exchange, and promotes the nucleation step of actin polymerisation [, ]. It can be regulated by Ca2+ and phosphoinositides []. The interaction between gelsolin and tropomyosin modulates actin dynamics []. Gelsolin also plays a role in ciliogenesis []. The structure of gelsolin has been solved []. In humans there are two forms of gelsolin generated by alternative splicing. One is the cytosolic form that has a role in the regulation of the actin cytoskelton [], the other is the secreted form that may be part of the actin scavenging system in the bloodstream []. Mutations in gelsolin gene cause familial amyloidosis of Finnish type (FAF) []. Short Name:  Gelsolin
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PTHR11977:SF29
PTHR11977:SF39

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0005509 IPR030004
GO:0045010 IPR030004
GO:0051014 IPR030004
GO:0051016 IPR030004

4 Ontology Annotations

GO Term Gene Name
GO:0005509 IPR030004
GO:0045010 IPR030004
GO:0051014 IPR030004
GO:0051016 IPR030004

1 Parent Features

DB identifier Type Name
IPR007122 Family Villin/Gelsolin

2 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
63570 C1N000 PAC:27344440 Micromonas pusilla CCMP1545 391  
19502 C1MZZ9 PAC:27344518 Micromonas pusilla CCMP1545 107  

9 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9288746
            3023087
            14527663
            23844991
            20393563
            3027569
            15336957
            6325429
            1314333