Protein Domain : IPR000945

Type:  Family Name:  Dopamine beta-hydroxylase-related
Description:  This family representsDopamine beta-monooxygenase (DBH) and related enzymes, including tyramine beta-hydroxylase, MOXD1 homologue 1/2 and DBH-like monooxygenase protein 1/2 [].DBH, also known as Dopamine beta-hydroxylase, is a class of ascorbate-dependent enzymes from the catecholamine biosynthetic pathway that requires copper as a cofactor and uses ascorbate as an electron donor. DBH catalyses the conversion of dopamine to the neurotransmitter norepinephrine:3,4-dihydroxyphenethylamine + ascorbate + O2= noradrenaline + dehydroascorbate + H2O DBH exists in both soluble (in chromaffin granules) and membrane bound forms. The protein functions as a homotetramer [, ]. Short Name:  DBH-rel
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3 Child Features

DB identifier Type Name
IPR028463 Family DBH-like monooxygenase protein 1
IPR028464 Family DBH-like monooxygenase protein 2
IPR028460 Family Tyramine beta-hydroxylase/Dopamine beta-hydroxylase

4 Contains

DB identifier Type Name
IPR000323 Domain Copper type II, ascorbate-dependent monooxygenase, N-terminal
IPR008977 Domain PHM/PNGase F domain
IPR014783 Conserved_site Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site
IPR020611 Conserved_site Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site

2 Cross Referencess

Identifier
PTHR10157
PR00767

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0055114 IPR000945

1 Ontology Annotations

GO Term Gene Name
GO:0055114 IPR000945

0 Parent Features

60 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
61406 C1ECG1 PAC:27401405 Micromonas sp RCC299 540  
Cre01.g015451.t1.1 A0A2K3E5Q3 PAC:30788927 Chlamydomonas reinhardtii 1122  
Cre01.g015300.t1.1 A8HPJ1 PAC:30789353 Chlamydomonas reinhardtii 796  
Cre10.g439300.t1.2 A0A2K3DAD9 PAC:30790349 Chlamydomonas reinhardtii 970  
Cre10.g428706.t1.1 A0A2K3D9Q1 PAC:30790328 Chlamydomonas reinhardtii 953  
Cre10.g428734.t1.1 A0A2K3D9P7 PAC:30789777 Chlamydomonas reinhardtii 1110  
Cre10.g428692.t1.1 A0A2K3D9P9 PAC:30790484 Chlamydomonas reinhardtii 894  
Cre10.g465700.t1.2 A0A2K3DC83 PAC:30790103 Chlamydomonas reinhardtii 1023  
Cre10.g450300.t1.1 A0A2K3DB44 PAC:30790177 Chlamydomonas reinhardtii 758  
Cre11.g480700.t1.1 A0A2K3D8Q1 PAC:30775521 Chlamydomonas reinhardtii 852  
Cre11.g480700.t2.1 A0A2K3D8N4 PAC:30775522 Chlamydomonas reinhardtii 850  
Cre11.g480350.t1.1 A0A2K3D8P1 PAC:30776006 Chlamydomonas reinhardtii 962  
Cre12.g539650.t1.1 A0A2K3D706 PAC:30792591 Chlamydomonas reinhardtii 4828  
Cre12.g545250.t1.1 A0A2K3D6K3 PAC:30792233 Chlamydomonas reinhardtii 930  
Cre12.g525000.t1.2 A0A2K3D4D8 PAC:30792608 Chlamydomonas reinhardtii 666  
Cre13.g569300.t1.1 A0A2K3CZJ9 PAC:30784291 Chlamydomonas reinhardtii 725  
Cre12.g557078.t1.1 A0A2K3D752 PAC:30792350 Chlamydomonas reinhardtii 884  
Cre13.g579700.t1.2 A0A2K3D0A1 PAC:30783875 Chlamydomonas reinhardtii 1200  
Cre16.g660300.t1.2 A0A2K3CTI0 PAC:30777864 Chlamydomonas reinhardtii 822  
Cre16.g652700.t1.1 A0A2K3CSZ0 PAC:30777938 Chlamydomonas reinhardtii 865  
Cre16.g694207.t1.1 A0A2K3CSF9 PAC:30777325 Chlamydomonas reinhardtii 840  
Cre02.g115100.t1.1 A0A2K3E382 PAC:30785484 Chlamydomonas reinhardtii 610  
Cre02.g117400.t1.1 A0A2K3E3F0 PAC:30786074 Chlamydomonas reinhardtii 1170  
Cre03.g201301.t1.2 A0A2K3DZB2 PAC:30787495 Chlamydomonas reinhardtii 901  
Cre03.g201300.t1.1 A0A2K3DZF2 PAC:30786822 Chlamydomonas reinhardtii 635  
Cre05.g236550.t1.2 A0A2K3DST8 PAC:30783412 Chlamydomonas reinhardtii 702  
Cre05.g236350.t1.1 A0A2K3DSS8 PAC:30783411 Chlamydomonas reinhardtii 695  
Cre05.g245100.t1.1 A0A2K3DS78 PAC:30783420 Chlamydomonas reinhardtii 1020  
Cre06.g278103.t1.1 A0A2K3DNU6 PAC:30779554 Chlamydomonas reinhardtii 650  
Cre07.g315850.t1.1 A0A2K3DIP3 PAC:30775368 Chlamydomonas reinhardtii 900  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2295597
            8656284
            6998654