Protein Domain : IPR026494

Type:  Family Name:  Ribonucleoside reductase subunit beta, NrdF
Description:  Ribonucleotide reductase (also known as ribonucleoside-diphosphate reductase) catalyses the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides providing the precursors necessary for DNA synthesis. Three main classes of ribonucleotide reductases (RNR) have been discovered that depend on different metal cofactors for the catalytic activity: class I enzymes contain a diiron-oxygen cluster, class II a cobalt containingcobalamin cofactor (vitamin B12), and class III an 4Fe-4S iron-sulfur cluster coupled to S-adenosylmethionine (SAM) [].Class I RNRs can be further divided into two subclasses, Ia and Ib. Class Ia exists in eukaryotes, prokaryotes, viruses, and bacteriophages, while Ib has only been found in prokaryotes. Class I RNRs are tetrameric enzymes (alpha2beta2). The small beta2-homodimer is called R2 in class Ia, encoded by nrdB, and R2F for the class Ib, encoded by nrdF []. Members of this family are NrdF, the beta subunit of class 1b ribonucleotide reductase. This form uses a dimanganese moiety associated with a tyrosine radical to reduce the cellular requirement for iron []. Short Name:  RNR_NrdF
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0 Child Features

0 Contains

1 Cross References

Identifier
TIGR04171

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0009263 IPR026494
GO:0005971 IPR026494

2 Ontology Annotations

GO Term Gene Name
GO:0009263 IPR026494
GO:0005971 IPR026494

1 Parent Features

DB identifier Type Name
IPR000358 Family Ribonucleotide reductase small subunit

1 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Pavir.9NG427000.1.p PAC:37659642 Panicum virgatum 322  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            15158709
            21561096