Protein Domain : IPR018113

Type:  Conserved_site Name:  Phosphotransferase system EIIB, cysteine phosphorylation site
Description:  The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS) [, ] is a major carbohydrate transport system in bacteria. The PTS catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. The general mechanism of the PTS is the following: a phosphoryl group from phosphoenolpyruvate (PEP) is transferred to enzyme-I (EI) of PTS which in turn transfers it to a phosphoryl carrier protein (HPr). Phospho-HPr then transfers the phosphoryl group to a sugar-specific permease which consists of at least three structurally distinct domains (IIA, IIB, and IIC) [] which can either be fused together in a single polypeptide chain or exist as two or three interactive chains, formerly called enzymes II (EII) and III (EIII).The first domain (IIA) carries the first permease-specific phoshorylation site, a histidine, which is phosphorylated by phospho-HPr. The second domain (IIB) is phosphorylated by phospho-IIA on a cysteinyl or histidyl residue, depending on the permease. Finally, the phosphoryl group is transferred from the IIB domain to the sugar substrate in a process catalyzed by the IIC domain; this process is coupled to the transmembrane transport of the sugar.This entry covers the phosphorylation site of EIIB domains. Short Name:  PTrfase_EIIB_Cys
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PF00367
PS01035

9 Found Ins

DB identifier Type Name
IPR001996 Domain Phosphotransferase system, IIB component, type 1
IPR011299 Domain PTS system glucose-specific IIBC component
IPR011296 Domain Phosphotransferase system, trehalose-specific IIBC component
IPR010974 Domain Phosphotransferase system, N-acetylglucosamine-specific IIBC component
IPR011297 Family Phosphotransferase system, beta-glucoside-specific IIABC component
IPR010975 Family Phosphotransferase system, alpha-glucoside-specific IIBC component
IPR011301 Family PTS system, maltose/glucose-specific IIBC component
IPR010973 Domain Phosphotransferase system, sucrose-specific IIBC component
IPR011300 Domain Phosphotransferase system, IIBC component

1 GO Annotation

GO Term Gene Name
GO:0008982 IPR018113

1 Ontology Annotations

GO Term Gene Name
GO:0008982 IPR018113

0 Parent Features

3 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Araha.11756s0077.1.p PAC:28856530 Arabidopsis halleri 478  
Brdisv1pangenome1005610m.p PAC:33624718 Brachypodium distachyon Pangenome 930  
Brdisv1BdTR11A1029459m.p PAC:35677832 Brachypodium distachyon BdTR11a 1082  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2197982
            8246840
            1537788