Protein Domain : IPR011297

Type:  Family Name:  Phosphotransferase system, beta-glucoside-specific IIABC component
Description:  The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS) [, ] is a major carbohydrate transport system in bacteria. The PTS catalyses the phosphorylation of incoming sugar substrates and coupled with translocation across the cell membrane, makes the PTS a link between the uptake and metabolism of sugars.The general mechanism of the PTS is the following: a phosphoryl group from phosphoenolpyruvate (PEP) is transferred via a signal transduction pathway, to enzyme I (EI) which in turn transfers it to a phosphoryl carrier, the histidine protein (HPr). Phospho-HPr then transfers the phosphoryl group to a sugar-specific permease, a membrane-bound complex known as enzyme 2 (EII), which transports the sugar to the cell. EII consists of at least three structurally distinct domains IIA, IIB and IIC []. These can either be fused together in a single polypeptide chain or exist as two or three interactive chains, formerly called enzymes II (EII) and III (EIII). The first domain (IIA or EIIA) carries the first permease-specific phosphorylation site, a histidine which is phosphorylated by phospho-HPr. The second domain (IIB or EIIB) is phosphorylated by phospho-IIA on a cysteinyl or histidyl residue, depending on the sugar transported. Finally, the phosphoryl group is transferred from the IIB domain to the sugar substrate concomitantly with the sugar uptake processed by the IIC domain. This third domain (IIC or EIIC) forms the translocation channel and the specific substrate-binding site. An additional transmembrane domain IID, homologous to IIC, can be found in some PTSs, e.g. for mannose [, , , ]. This entry represents a family of PTS enzyme II proteins in which all three domains are found in the same polypeptide chain and which appear to have a broad specificity for beta-glucosides including salicin (beta-D-glucose-1-salicylate) and arbutin (hydroquinone-O-beta-D-glucopyranoside) []. These are distinct from the closely related sucrose-specific and trehalose-specific PTS transporters. Short Name:  PTS_IIABC_b_glu
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0 Child Features

4 Contains

DB identifier Type Name
IPR001127 Domain Phosphotransferase system, sugar-specific permease EIIA type 1
IPR001996 Domain Phosphotransferase system, IIB component, type 1
IPR018113 Conserved_site Phosphotransferase system EIIB, cysteine phosphorylation site
IPR003352 Domain Phosphotransferase system, EIIC

1 Cross References

Identifier
TIGR01995

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0008982 IPR011297
GO:0009401 IPR011297
GO:0005886 IPR011297

3 Ontology Annotations

GO Term Gene Name
GO:0008982 IPR011297
GO:0009401 IPR011297
GO:0005886 IPR011297

0 Parent Features

1 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brdisv1BdTR11A1044329m.p PAC:35696163 Brachypodium distachyon BdTR11a 1038  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2197982
            8246840
            1537788
            7815935
            11361063
            7883710