Protein Domain : IPR001996

Type:  Domain Name:  Phosphotransferase system, IIB component, type 1
Description:  The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS) [, ] is a major carbohydrate transport system in bacteria. The PTS catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. The general mechanism of the PTS is the following: a phosphoryl group from phosphoenolpyruvate (PEP) is transferred to enzyme-I (EI) of PTS which in turn transfers it to a phosphoryl carrier protein (HPr). Phospho-HPr then transfers the phosphoryl group to a sugar-specific permease which consists of at least three structurally distinct domains (IIA, IIB, and IIC) [] which can either be fused together in a single polypeptide chain or exist as two or three interactive chains, formerly called enzymes II (EII) and III (EIII).The first domain (IIA) carries the first permease-specific phoshorylation site, a histidine, which is phosphorylated by phospho-HPr. The second domain (IIB) is phosphorylated by phospho-IIA on a cysteinyl or histidyl residue, depending on the permease. Finally, the phosphoryl group is transferred from the IIB domain to the sugar substrate in a process catalyzed by the IIC domain; this process is coupled to the transmembrane transport of the sugar.Several PTS permease families are currently recognised, namely, the (i) glucose (including glucoside), (ii) fructose (including mannitol), (iii) lactose (including N,N-diacetylchitobiose), (iv) galactitol, (v) glucitol, (vi) mannose, and (vii) l-ascorbate families [].This entry represents the component IIB of the glucose family of PTS systems (type 1). Short Name:  PTS_IIB_1
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0 Child Features

1 Contains

DB identifier Type Name
IPR018113 Conserved_site Phosphotransferase system EIIB, cysteine phosphorylation site

4 Cross Referencess

Identifier
PS51098
TIGR00826
G3DSA:3.30.1360.60
SSF55604

8 Found Ins

DB identifier Type Name
IPR011299 Domain PTS system glucose-specific IIBC component
IPR011296 Domain Phosphotransferase system, trehalose-specific IIBC component
IPR010974 Domain Phosphotransferase system, N-acetylglucosamine-specific IIBC component
IPR011297 Family Phosphotransferase system, beta-glucoside-specific IIABC component
IPR010975 Family Phosphotransferase system, alpha-glucoside-specific IIBC component
IPR011301 Family PTS system, maltose/glucose-specific IIBC component
IPR010973 Domain Phosphotransferase system, sucrose-specific IIBC component
IPR011300 Domain Phosphotransferase system, IIBC component

2 GO Annotations

GO Term Gene Name
GO:0008982 IPR001996
GO:0009401 IPR001996

2 Ontology Annotations

GO Term Gene Name
GO:0008982 IPR001996
GO:0009401 IPR001996

0 Parent Features

88 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Potri.002G054300.2 PAC:27020704 Populus trichocarpa 417  
Potri.002G054300.1 A0A2K2BDW5 PAC:27020703 Populus trichocarpa 424  
Gorai.009G311900.2 A0A0D2QRD9 PAC:26768021 Gossypium raimondii 197  
Migut.E01686.1.p PAC:28921791 Mimulus guttatus 58  
Araha.11756s0077.1.p PAC:28856530 Arabidopsis halleri 478  
Cre12.g554800.t1.2 A8IYP4 PAC:30793573 Chlamydomonas reinhardtii 375  
SapurV1A.8169s0010.1.p PAC:31412541 Salix purpurea 92  
evm_27.model.AmTr_v1.0_scaffold00117.52 W1NQE0 PAC:31555958 Amborella trichopoda 281  
Eucgr.A01932.1.p A0A059DGF9 PAC:32046831 Eucalyptus grandis 541  
GSMUA_Achr9P22830_001 PAC:32306622 Musa acuminata 120  
Manes.10G049200.3.p A0A2C9V5F7 PAC:32367489 Manihot esculenta 200  
Sphfalx0028s0084.1.p PAC:32627177 Sphagnum fallax 291  
Aco027023.1 PAC:33041956 Ananas comosus 187  
Brdisv1pangenome1005610m.p PAC:33624718 Brachypodium distachyon Pangenome 930  
Brdisv1BdTR11A1029459m.p PAC:35677832 Brachypodium distachyon BdTR11a 1082  
Brdisv1BdTR11A1044329m.p PAC:35696163 Brachypodium distachyon BdTR11a 1038  
Tp57577_TGAC_v2_mRNA11004 PAC:35992441 Trifolium pratense 187  
Tp57577_TGAC_v2_mRNA33723 PAC:35973046 Trifolium pratense 286  
AUR62032717-RA PAC:36307518 Chenopodium quinoa 143  
Phvul.002G296200.1.p V7CTD2 PAC:37174451 Phaseolus vulgaris 622  
Potri.002G054300.2.p B9GSP9 PAC:37257902 Populus trichocarpa 404  
Potri.002G054300.1.p A0A2K2BDW5 PAC:37257901 Populus trichocarpa 424  
Podel.02G059700.1.p PAC:37297616 Populus deltoides WV94 425  
Pavir.8KG121000.1.p PAC:37600316 Panicum virgatum 709  
Oeu048040.1 PAC:37739700 Olea europaea 169  
Oeu016857.1 PAC:37736790 Olea europaea 502  
evm.model.Scaffold_671.1166 PAC:37852361 Coffea arabica 770  
evm.model.Scaffold_571.826 PAC:37886956 Coffea arabica 770  
Gohir.A05G294600.2.p PAC:38118404 Gossypium hirsutum 197  
HORVU3Hr1G034270.2 PAC:38411476 Hordeum vulgare 397  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2197982
            8246840
            1537788
            16339738