3 Ontology Annotations
GO Term | Gene Name |
---|---|
GO:0003677 | IPR011539 |
GO:0003700 | IPR011539 |
GO:0006355 | IPR011539 |
1 Parent Features
DB identifier | Type | Name |
---|---|---|
IPR008967 | Domain | p53-like transcription factor, DNA-binding |
Type: | Domain | Name: | Rel homology domain (RHD), DNA-binding domain |
Description: | The Rel homology domain (RHD) is found in a family of eukaryotic transcription factors, which includes NF-kappaB, Dorsal, Relish, NFAT, among others. The RHD is composed of two structural domains: the N-terminal DNA binding domain that is similar to that found in P53, the C-terminal domain has an immunoglobulin-like fold (See ) that functions as a dimerisation domain. This entry represents the N-terminal DNA binding domain []. Some of these transcription factors appear to form multi-protein DNA-bound complexes []. Phosphorylation of the RHD appears to play a role in the regulation of some of these transcription factors, acting to modulate the expression of their target genes []. The RHD is composed of two immunoglobulin-like beta-barrel subdomains that grip the DNA in the major groove. The N-terminal specificity domain resembles the core domain of the p53 transcription factor, and contains a recognition loop that interacts with DNA bases; the C-terminal dimerisation domain contains the site for interaction with I-kappaB []. | Short Name: | RHD_DNA_bind_dom |
GO Term | Gene Name |
---|---|
GO:0003677 | IPR011539 |
GO:0003700 | IPR011539 |
GO:0006355 | IPR011539 |
DB identifier | Type | Name |
---|---|---|
IPR008967 | Domain | p53-like transcription factor, DNA-binding |