Protein Domain : IPR011363

Type:  Family Name:  Dorsal/Dif protein
Description:  The Dorsal morphogen directs formation of the Drosophila dorsoventral axis by both activating and repressing transcription. It contains an N-terminal Rel homology domain (RHD), which is responsible for DNA binding and regulated nuclear import, and a C-terminal domain (CTD) that contains activation and repression motifs []. In wild-type embryos, the dorsal protein is found in the cytoplasm during cleavage. After the nuclei migrate to the periphery of the embryo, a ventral-to-dorsal gradient of nuclear dorsal protein is established [].Dorsal-related immunity factor Dif does not appear to participate in dorsoventral patterning, but instead mediates an immune response in Drosophila larvae. Dif is normally localised in the cytoplasm of the larval fat body, but quickly accumulates in the nucleus upon bacterial infection or injury. Once in the nucleus, Dif binds to kappa B-like sequence motifs present in promoter regions of immunity genes []. Short Name:  Dorsal/Dif
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0 Child Features

3 Contains

DB identifier Type Name
IPR013783 Domain Immunoglobulin-like fold
IPR002909 Domain IPT domain
IPR011539 Domain Rel homology domain (RHD), DNA-binding domain

2 Cross Referencess

Identifier
PTHR24169:SF20
PIRSF001716

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0003700 IPR011363
GO:0006357 IPR011363
GO:0005634 IPR011363
GO:0005737 IPR011363

4 Ontology Annotations

GO Term Gene Name
GO:0003700 IPR011363
GO:0006357 IPR011363
GO:0005634 IPR011363
GO:0005737 IPR011363

1 Parent Features

DB identifier Type Name
IPR000451 Family NF-kappa-B/Dorsal

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12077338
            3118464
            8242747