Protein Domain : IPR000451

Type:  Family Name:  NF-kappa-B/Dorsal
Description:  The transcription factor NF-kB (Nuclear Factor-kappaB) was first identified as a DNA-binding protein specific for the 10-base pair kB site in the immunoglobulin k light-chain enhancer of B lymphocytes [], but has subsequently been found in many different cell types. NF-kB represents a group of structurally related proteins that share a 300 amino acid `Rel homology domain' (RHD) []: members include p50 (NF-kB1), p52 (NF-kB2), p65 (RelA), c-Rel, v-Rrel, RelB, and the Drosophila proteins Dorsal and Dif. These proteins exist as homo- and heterodimers that bind to kB sites in the enhancer regions of several target genes, most of which are involved in cellular defence mechanisms and differentiation.The RHD, which is located N-terminally, is responsible for protein dimerisation, DNA binding and nuclear localisation. The more variableC-terminal transactivation domain is found in RelA, RelB and c-Rel, but not in p50 or p52. Nevertheless, p50 and p52 play critical roles in modulating the specificity of NF-kB function. DNA binding requires the entire RHD, by contrast with other eukaryotic and prokaryotic transcription factors, where muchsmaller DNA-binding domains confer full specificity and binding affinity for the target []. The structure of the transcription factor NF-kB p50 homodimer bound to a palindromic kB site shows the RHD to fold into 2 distinct subdomains, similar to the beta-sandwich structure of the immunoglobulins [].NF-kB is expressed in the cytoplasm of virtually all cell types, where its activity is controlled by a family of regulatory proteins, called inhibitors of NF-kB (IkB) [, ]. Short Name:  NFkB/Dor
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6 Child Features

DB identifier Type Name
IPR011363 Family Dorsal/Dif protein
IPR030495 Family Transcription factor RelA (p65)
IPR030496 Family Transcription factor RelB
IPR030497 Family Nuclear factor NF-kappa-B, p100 subunit
IPR030503 Family Nuclear factor NF-kappa-B, p105 subunit
IPR030505 Family Proto-oncogene c-Rel

3 Contains

DB identifier Type Name
IPR013783 Domain Immunoglobulin-like fold
IPR002909 Domain IPT domain
IPR011539 Domain Rel homology domain (RHD), DNA-binding domain

2 Cross Referencess

Identifier
PTHR24169
PR00057

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0003700 IPR000451
GO:0006355 IPR000451
GO:0005634 IPR000451
GO:0005737 IPR000451

4 Ontology Annotations

GO Term Gene Name
GO:0003700 IPR000451
GO:0006355 IPR000451
GO:0005634 IPR000451
GO:0005737 IPR000451

0 Parent Features

0 Proteins

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2018779
            7530332
            17114415
            15371334
            22302935