Protein Domain : IPR006187

Type:  Family Name:  Claudin
Description:  Claudins form the paracellular tight junction seal in epithelial tissues. In humans, 24 claudins (claudin 1-24) have been identified. Their ability to polymerise and form strands is affected by the cell types [, , ]. They can also form heteropolymers with each other within and between tight junction strands []. Most of the claudins (claudin-12 being the exception) have a C-terminal PDZ-binding motif that can interact with other PDZ domain proteins, such as scaffolding protein, ZO-1, -2 and -3 []. They also interact with non-tight junction proteins, such as cell adhesion proteins EpCam and tetraspanins and the signaling proteins, ephrin A and B and their receptors, EphA and EphB []. Short Name:  Claudin
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15 Child Features

DB identifier Type Name
IPR005411 Family Claudin-2
IPR003548 Family Claudin-1
IPR003549 Family Claudin-3
IPR003550 Family Claudin-4
IPR003551 Family Claudin-5
IPR003552 Family Claudin-7
IPR003553 Family Claudin-9
IPR003554 Family Claudin-10
IPR003555 Family Claudin-11
IPR003556 Family Claudin-14
IPR003925 Family Claudin-6
IPR003926 Family Claudin-8
IPR003927 Family Claudin-16
IPR003928 Family Claudin-18
IPR008094 Family Claudin-15

1 Contains

DB identifier Type Name
IPR017974 Conserved_site Claudin, conserved site

1 Cross References

Identifier
PTHR12002

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0005198 IPR006187
GO:0005923 IPR006187

2 Ontology Annotations

GO Term Gene Name
GO:0005198 IPR006187
GO:0005923 IPR006187

1 Parent Features

DB identifier Type Name
IPR004031 Family PMP-22/EMP/MP20/Claudin superfamily

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            24665401
            20188437
            21372174
            10562289