| Type: | Family | Name: | Claudin-1 |
| Description: | Claudins form the paracellular tight junction seal in epithelial tissues. In humans, 24 claudins (claudin 1-24) have been identified. Their ability to polymerise and form strands is affected by the cell types [, , ]. They can also form heteropolymers with each other within and between tight junction strands []. Most of the claudins (claudin-12 being the exception) have a C-terminal PDZ-binding motif that can interact with other PDZ domain proteins, such as scaffolding protein, ZO-1, -2 and -3 []. They also interact with non-tight junction proteins, such as cell adhesion proteins EpCam and tetraspanins and the signaling proteins, ephrin A and B and their receptors, EphA and EphB [].Claudin-1 was the first member of the claudin family to be identified as a tight junction component []. The human isoform of claudin-1 was originally termed senescence-associated epithelial membrane protein 1 (SEMP1) [], but has since been reclassified. | Short Name: | Claudin1 |
