3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0005542 | IPR004227 |
| GO:0016740 | IPR004227 |
| GO:0008152 | IPR004227 |
| Type: | Domain | Name: | Formiminotransferase catalytic domain |
| Description: | This entry represents the formiminotransferase (FT) domain of formiminotransferase-cyclodeaminase (FTCD), which forms a homodimer, with each protomer being comprised of two subdomains. Each subdomain has the structure consisting of an alpha/beta sandwich with antiparallel beta-sheet in the form (beta-alpha-beta)x2. Tetrahydrofolate (THF)-dependent glutamate formiminotransferase is involved in the histidine utilization pathway. This enzyme interconverts L-glutamate and N-formimino-L-glutamate. The enzyme is bifunctional as it also catalyzes the cyclodeaminase reaction on N-formimino-THF, converting it to 5,10-methenyl-THF and releasing ammonia; part of the process of regenerating THF. This model covers enzymes from metazoa as well as Gram-positive bacteria and archaea. In humans, deficiency of this enzyme results in a disease phenotype []. The crystal structure of the enzyme has been studied in the context of the catalytic mechanism []. | Short Name: | Formiminotransferase_cat |
| GO Term | Gene Name |
|---|---|
| GO:0005542 | IPR004227 |
| GO:0016740 | IPR004227 |
| GO:0008152 | IPR004227 |
