Protein Domain : IPR022384

Type:  Domain Name:  Formiminotransferase subdomain
Description:  This entry represents the formiminotransferase (FT) domain of formiminotransferase-cyclodeaminase (FTCD), which forms a homodimer, with each protomer being comprised of two subdomains. Each subdomain has the structure consisting of an alpha/beta sandwich with antiparallel beta-sheet in the form (beta-alpha-beta)x2. Tetrahydrofolate (THF)-dependent glutamate formiminotransferase is involved in the histidine utilization pathway. This enzyme interconverts L-glutamate and N-formimino-L-glutamate. The enzyme is bifunctional as it also catalyzes the cyclodeaminase reaction on N-formimino-THF, converting it to 5,10-methenyl-THF and releasing ammonia; part of the process of regenerating THF. This model covers enzymes from metazoa as well as Gram-positive bacteria and archaea. In humans, deficiency of this enzyme results in a disease phenotype []. The crystal structure of the enzyme has been studied in the context of the catalytic mechanism [].This entry represents both individual subdomains of the formiminotransferase catalytic domain. Short Name:  FormiminoTrfase_subdom
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2 Child Features

DB identifier Type Name
IPR012886 Domain Formiminotransferase, N-terminal subdomain
IPR013802 Domain Formiminotransferase, C-terminal subdomain

0 Contains

1 Cross References

Identifier
SSF55116

1 Found In

DB identifier Type Name
IPR004227 Domain Formiminotransferase catalytic domain

3 GO Annotations

GO Term Gene Name
GO:0005542 IPR022384
GO:0016740 IPR022384
GO:0008152 IPR022384

3 Ontology Annotations

GO Term Gene Name
GO:0005542 IPR022384
GO:0016740 IPR022384
GO:0008152 IPR022384

0 Parent Features

727 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
438865 D8R013 PAC:15401940 Selaginella moellendorffii 294  
evm.model.supercontig_17.168 PAC:16410664 Carica papaya 271  
29983.m003257 B9RW59 PAC:16815022 Ricinus communis 300  
29983.m003258 B9RW60 PAC:16815023 Ricinus communis 299  
Cucsa.119520.1 A0A0A0KAE4 PAC:16960995 Cucumis sativus 324  
Cucsa.119530.1 A0A0A0KAZ4 PAC:16960996 Cucumis sativus 299  
Cucsa.119530.2 A0A0A0KAZ4 PAC:16960997 Cucumis sativus 299  
orange1.1g020781m A0A067DQF9 PAC:18117742 Citrus sinensis 321  
orange1.1g026946m A0A067DYV2 PAC:18117743 Citrus sinensis 230  
orange1.1g029879m A0A067DXR0 PAC:18117744 Citrus sinensis 186  
orange1.1g039996m A0A067DLD7 PAC:18117751 Citrus sinensis 241  
AT2G20830.3 F4IFJ9 PAC:19639785 Arabidopsis thaliana 341  
AT2G20830.2 F4IFK0 PAC:19639784 Arabidopsis thaliana 431  
AT2G20830.1 Q9SKT4 PAC:19639786 Arabidopsis thaliana 297  
Thhalv10001991m V4MDC1 PAC:20200420 Eutrema salsugineum 431  
Ciclev10001997m V4SVF9 PAC:20788669 Citrus clementina 300  
Ciclev10016537m V4UE92 PAC:20817516 Citrus clementina 230  
Ciclev10015950m V4U3W2 PAC:20817515 Citrus clementina 321  
Ciclev10017445m V4TJI3 PAC:20815739 Citrus clementina 424  
Lus10018558 PAC:23180377 Linum usitatissimum 303  
Lus10018559 PAC:23180440 Linum usitatissimum 307  
Lus10039789 PAC:23165135 Linum usitatissimum 298  
Lus10039790 PAC:23165283 Linum usitatissimum 309  
Potri.013G145700.1 A0A2K1Y5P9 PAC:26994772 Populus trichocarpa 299  
Potri.013G145600.1 B9I687 PAC:26995945 Populus trichocarpa 316  
Potri.013G145600.2 A0A2K1Y5U1 PAC:26995946 Populus trichocarpa 300  
Potri.019G104700.1 A0A2K1WSE5 PAC:27026271 Populus trichocarpa 316  
Gorai.005G205100.1 A0A0D2PWH9 PAC:26802457 Gossypium raimondii 468  
14777 I0YZZ2 PAC:27391106 Coccomyxa subellipsoidea C-169 301  
151974 C1MPD0 PAC:27347566 Micromonas pusilla CCMP1545 337  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10673422
            12815595