| Type: | Family | Name: | Suppressor of cytokine signalling |
| Description: | Suppressor of cytokine signalling (SOCS) proteins form part of a classical negative feedback system that regulates cytokine signal transduction. The SOCS family consists of SOCS1-SOCS7 and CIS, all sharing a central SH2 domain and a C-terminal SOCS box []. Expression of CIS, SOCS-1, SOCS-2 and SOCS-3 is induced by various cytokines. SOCS family members modulate signaling by several mechanisms, which include inactivation of the Janus kinases (JAKs), blocking access of the signal transducers and activators of transcription (STATs) to receptor binding sites, and ubiquitination of signaling proteins and their subsequent targeting to the proteasome []. | Short Name: | SOCS |
| DB identifier | Type | Name |
|---|---|---|
| IPR028414 | Family | Suppressor of cytokine signalling 3 |
| IPR028416 | Family | Suppressor of cytokine signalling 4 |
| IPR028410 | Family | Suppressor of cytokine signalling 2 |
| IPR028411 | Family | Suppressor of cytokine signalling 1 |
| IPR028420 | Family | Suppressor of cytokine signalling 5 |
| IPR028421 | Family | Suppressor of cytokine signalling 6 |
| IPR028423 | Family | Suppressor of cytokine signalling 7 |
| IPR028425 | Family | Cytokine-inducible SH2-containing protein |
